水凝胶在内耳局部药物递送中的研究进展  

Progress of Research on Hydrogel for Local Drug Delivery to the Inner Ear

作　　者：熊海霞 刁明芳 XIONG Haixia;DIAO Mingfang(Department of Endoscopic Ear Surgery,Senior Department of Otorhinolaryngology Head and Neck Surgery,The Sixth Medical Center of PLA General Hospital,Beijing 100048,China)

机构地区：[1]中国人民解放军总医院第六医学中心耳鼻咽喉头颈外科医学部耳内镜外科,北京100048 [2]华南理工大学医学院

出　　处：《中华耳科学杂志》2024年第2期335-338,共4页Chinese Journal of Otology

基　　金：首都卫生发展科研专项基金资助(首发-2022-2-5072)。

摘　　要：水凝胶一般由强亲水性的三维网状结构组成,是一种具备软组织特性的半固体聚集态凝胶,既可维持特定的形态,亦可实现药物分子从凝胶基质中的扩散和渗透。由于其独特的网状结构及较高的黏滞性,更有利于药物在中耳腔的滞留。与药物溶液相比,使用水凝胶经鼓室注射,可减少给药次数,实现药物缓慢、长效释放。我们对目前内耳局部药物递送系统中所使用水凝胶的分类、特性、疗效及其研究进展作统一论述。Hydrogel is generally composed of a three-dimensional network structure with strong hydrophilicity,which is a semi-solid aggregation gel with soft tissue characteristics.It can not only maintain a specific form,but also achieve diffusion and penetration of drug molecules from the gel matrix.Because of its unique network structure and high viscosity,it is more conducive to retention of drugs in the middle ear cavity.Compared with drug solutions,hydrogel via intratympanic injection can reduce administration frequency and achieve sustained drug release.In this paper,we reviewed the classification,characteristics,efficacy and progress of research on hydrogels based local drug delivery systems for inner ear drug administration.

关 键 词：水凝胶 内耳给药 泊洛沙姆407 纳米颗粒 

分 类 号：R764[医药卫生—耳鼻咽喉科]