细胞自噬在脑缺血损伤中的作用及中药调控机制  

Role of cellular autophagy in cerebral ischemic injury and the regulatory mechanism of traditional Chinese medicine

作　　者：周盼盼[1] 崔应麟[2] 张文涛[2] 王姝瑞 陈佳慧 杨潼 Zhou Panpan;Cui Yinglin;Zhang Wentao;Wang Shurui;Chen Jiahui;Yang Tong(The Second Clinical Medical College of Henan University of Chinese Medicine,Zhengzhou 450002,Henan Province,China;Henan Provincial Hospital of Traditional Chinese Medicine,Zhengzhou 450002,Henan Province,China)

机构地区：[1]河南中医药大学第二临床医学院,河南省郑州市450002 [2]河南省中医院,河南省郑州市450002

出　　处：《中国组织工程研究》2025年第8期1650-1658,共9页Chinese Journal of Tissue Engineering Research

基　　金：河南省中医药科学研究专项课题(2023ZY1007,212102311123,2019ZY2003,2017ZY1020),项目负责人:崔应麟;具身视角下河南省中医药健康旅游发展现状及对策研究(TCM2022018),项目负责人:杨潼;国家中医药管理局2022年第二届全国名中医传承工作室建设项目(国中医药办人教函〔2022〕245号),项目负责人:崔应麟。

摘　　要：背景:研究表明缺血诱发的细胞自噬失调是脑损伤的关键因素,自噬相关基因6、微管相关蛋白轻链3、p62等自噬关键蛋白参与神经元轴突变性、死亡、细胞内稳态维持等过程,对神经功能的恢复起重要作用。目的:综述细胞自噬在脑缺血损伤中的作用及中药调控机制的研究进展。方法:第一作者以“缺血性中风,脑组织损伤,细胞自噬,信号通路,中药,复方,萜类,生物碱,黄酮,皂苷,木脂素,苯酞类等”为中文检索词,以“Ischemic stroke,brain tissue damage,cellular autophagy,signaling pathways,traditional Chinese medicine,compounds,terpenoids,alkaloids,flavonoids,saponins,lignans,phthalates”为英文检索词,检索2016年1月至2024年2月中国知网和PubMed数据库中有关细胞自噬在脑缺血损伤中的作用及中药调控机制的文献,排除与文章相关性不高、重复及过时的文献。共检索出1746篇相关文献,最终纳入92篇文献进行综述。结果与结论:大量文献研究证实,细胞自噬在脑缺血损伤中具有重要作用,适度的自噬可促进细胞存活,过度自噬则加重脑损伤;而中药可在脑缺血的不同时期,通过调节PI3K/Akt/mTOR、AMPK-mTOR及丝裂原激活蛋白激酶等信号通路,调节自噬相关蛋白表达,抑制神经元坏死、凋亡,发挥神经保护作用。BACKGROUND:Studies have shown that ischemia-induced cellular autophagy dysfunction is a key factor in brain injury.Autophagy related genes 6(ATG6),microtubule-associated protein 1 light chain(LC3),p62,and other autophagy key proteins are involved in the processes such as neuronal axonal degeneration,death,and intracellular homeostasis maintenance,playing an important role in the recovery of neural function.OBJECTIVE:To review the research progress in the role of cellular autophagy in cerebral ischemic injury and the regulatory mechanism of traditional Chinese medicine.METHODS:The first author used“ischemic stroke,brain tissue injury,cellular autophagy,signaling pathways,traditional Chinese medicine compounds,terpenoids,alkaloids,flavonoids,saponins,lignans,phthalates”as Chinese and English keywords respectively to search for literature on autophagy,cerebral ischemic injury,and the regulatory mechanisms of traditional Chinese medicine from China National Knowledge Infrastructure(CNKI)and PubMed databases from January 2016 to February 2024.Literature that is not highly relevant,repetitive,or outdated was excluded.A total of 1746 relevant literature were retrieved,and 92 articles were ultimately included.RESULTS AND CONCLUSION:Numerous studies have confirmed that autophagy plays an important role in cerebral ischemic injury.Moderate autophagy can promote cell survival,while excessive autophagy exacerbates brain injury.Traditional Chinese medicine can regulate the expression of autophagy related proteins,inhibit neuronal necrosis and apoptosis,and exert neuroprotective effects at different stages of cerebral ischemia by regulating signaling pathways such as PI3K/Akt/mTOR,AMPK-mTOR,and mitogen activated protein kinase.

关 键 词：脑缺血损伤 细胞自噬 中医药 作用机制 研究进展 

分 类 号：R459.9[医药卫生—治疗学] R318[医药卫生—临床医学] R242