中老年人群甘油三酯葡萄糖乘积指数与高血压的关联研究  

Association between triglyceride-glucose index and hypertension in middle-aged and older adults

作　　者：赵建勇[1] 郭春月 宋翠 ZHAO Jianyong;GUO Chunyue;SONG Cui(Department of Intensive Care Unit,the Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300250,China;Research Center,the Third Central Hospital of Tianjin,Tianjin 300170,China;Department of Cardiopulmonary Function,Tianjin Cancer Hospital Airport Hospital,Tianjin 300308,China)

机构地区：[1]天津中医药大学第二附属医院重症医学科,天津市300250 [2]天津市第三中心医院研究中心,天津市300170 [3]天津市肿瘤医院空港医院心肺功能科,天津市300308

出　　处：《中国动脉硬化杂志》2024年第7期583-589,共7页Chinese Journal of Arteriosclerosis

基　　金：天津市自然科学基金项目(21JCQNJC01460);天津市卫生健康科技项目(TJWJ2023QN044)。

摘　　要：[目的]探讨中国中老年人群中甘油三酯葡萄糖乘积(TyG)指数与高血压患病风险的相关性,为高血压的防治提供科学依据。[方法]数据来源于2011年中国健康与养老追踪调查(CHARLS)数据库,采用多阶段分层抽样方法选择研究对象。采用限制性立方样条回归模型分析TyG指数与高血压风险的剂量-反应关系。采用多因素非条件Logistic回归模型评估TyG指数与高血压患病风险之间的关联。[结果]共9987例研究对象纳入分析,平均年龄为(59.16±9.43)岁,其中男性4707(47.13%)例。限制性立方样条回归模型结果显示,随着TyG指数的升高,高血压的患病风险增加,呈线性关联(总体关联检验P<0.0001,非线性关联检验P=0.2019)。多因素Logistic回归模型结果表明,与Q1(TyG指数<8.23)相比,Q2(8.23≤TyG指数<8.59)、Q3(8.59≤TyG指数<9.04)和Q4(TyG指数≥9.04)时,高血压的患病风险[OR(95%CI)]分别为1.09(0.95~1.26)、1.53(1.33~1.76)、1.77(1.52~2.06)。[结论]随着TyG指数的升高,高血压的患病风险逐渐增加。TyG指数可能是高血压患病的独立危险因素。Aim To investigate the relationship between triglyceride-glucose(TyG)index and the risk of hypertension in middle-aged and older adults in China,and to provide scientific basis for the prevention and treatment of hypertension.Methods Data were obtained from the China health and retirement longitudinal study(CHARLS)in 2011.A multi-stage stratified sampling method was used to select participants.Restricted cubic spline regression model was used to analyze the dose-response relationship between TyG index and the risk of hypertension.Multivariate unconditional Logistic regression model was used to evaluate the association between TyG index and the risk of hypertension.Results A total of 9987 subjects were included in the analysis,with an average age of(59.16±9.43)years,including 4707 males(47.13%).The restricted cubic spline regression model showed that the risk of hypertension increased with the elevation of TyG index,and there was a linear association(overall association test P<0.0001,non-linear association test P=0.2019).The results of multivariate Logistic regression model showed that compared with Q1(TyG index<8.23),the OR(95%CI)of hypertension with Q2(8.23≤TyG index<8.59),Q3(8.59≤TyG index<9.04)and Q4(TyG index≥9.04),were 1.09(0.95~1.26),1.53(1.33~1.76)and 1.77(1.52~2.06),respectively.Conclusions With the increase of TyG index,the risk of hypertension gradually increased.TyG index may be an independent risk factor of hypertension.

关 键 词：甘油三酯葡萄糖乘积指数 高血压 中老年人 

分 类 号：R5[医药卫生—内科学]