克罗恩病患者左脑岛及右后顶叶皮层厚度与功能连接异常  

Abnormal cortical thickness and functional connectivity of the left insula and right posterior parietal cortex in Crohn's disease

作　　者：郑妍玲 李芸菲 胡杨 戎兰 周滟[5] 梁宗辉[1] ZHENG Yanling;LI Yunfei;HU Yang;RONG Lan;ZHOU Yan;LIANG Zonghui(Department of Radiology,Jing'an District Centre Hospital of Shanghai,Fudan University,Shanghai 200040,China;Department of Radiology,the Fifth People's Hospital of Shanghai,Fudan University,Shanghai 200240,China;Bi-Liang Brain Imaging Group,Liangjiang New Area,Chongqing 401120,China;Department of Gastroenterology,Huashan Hospital,Fudan University,Shanghai 200040,China;Department of Radiology,Renji Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai 200001,China)

机构地区：[1]复旦大学附属上海市静安区中心医院(华山医院静安分院)放射科,上海200040 [2]复旦大学附属上海市第五人民医院放射科,上海200240 [3]两江新区比量成像信息技术工作室,重庆401120 [4]复旦大学附属华山医院消化科,上海200040 [5]上海交通大学医学院附属仁济医院放射科,上海200001

出　　处：《磁共振成像》2024年第6期31-35,共5页Chinese Journal of Magnetic Resonance Imaging

基　　金：上海市“科技创新行动计划”医学创新研究专项(编号:21Y11910600);闵行区医技医药人才培养计划项目(编号:mwyjyx06)。

摘　　要：目的从结构和功能两个层面,探讨克罗恩病(Crohn's disease,CD)患者大脑是否存在变化,并分析与焦虑、抑郁评分的关系。材料与方法收集20例CD患者及21例正常对照组大脑结构与静息态功能磁共振影像及临床指标数据。基于Schaefer分区模板,将全脑分为100个脑区,分析脑区皮层厚度是否存在差异。计算结构差异脑区间功能连接(functional connectivity,FC),比较两组间FC是否存在差异。最后,使用皮尔逊相关系数衡量差异脑区皮层厚度和FC与临床指标(焦虑评分、抑郁评分、CD活动指数、病程)的相关性。结果与正常对照组相比,CD组左脑岛(P=0.002,FDR校正)、右后顶叶(P=0.031,FDR校正)皮层厚度下降。与正常对照组相比,CD组左脑岛-右后顶叶间FC显著降低(P=0.025);CD患者左脑岛皮层厚度与抑郁评分存在显著负相关(r=−0.61,P=0.007)。结论CD患者较正常对照左脑岛和右后顶叶皮层结构和FC受损,左脑岛皮层厚度变薄与抑郁评分增加有关,这为理解CD的神经机制提供新的线索。Objective:To investigate the alterations in brain structure and function among patients with Crohn's disease(CD)and their correlation with clinical indicators.Materials and Methods:Brain structural and resting-state functional magnetic resonance imaging data,along with clinical indicator data,were collected from 20 CD patients and 21 healthy controls.Based on the Schaefer atlas,the left and right hemispheres were divided into 100 brain regions,and the differences in cortical thickness between the two groups were examined.Functional connectivity(FC)was calculated among the brain regions showing significant structural group difference,and the differences in FC between the two groups were compared.The associations between clinical indicators[Self-rating Anxiety Scale(SAS)score,Self-rating Depression Scale(SDS)score,CD activity index and disease duration]and abnormal cortical thickness&FC were measured using Pearson correlation coefficient in CD group.Results:Compared to the healthy control group,CD patients exhibited a decrease in cortical thickness in the left insula(P=0.002,FDR correction)and right posterior parietal cortex(P=0.031,FDR correction).The FC between the left insula and right posterior parietal cortex was significantly reduced in CD group(P=0.025).Furthermore,there was a significant negative correlation between cortical thickness of left insula and SDS score among CD patients(r=−0.61,P=0.007).Conclusions:The left insular and right posterior parietal cortex structure and FC are damaged in CD patients compared with normal controls.The thickness of left insular cortex is associated with the increase of depression score,which provides new clues for understanding the neural mechanism of CD.

关 键 词：克罗恩病 神经机制 功能磁共振 结构磁共振 磁共振成像 

分 类 号：R445.2[医药卫生—影像医学与核医学] R574.62[医药卫生—诊断学]