血尿酸、载脂蛋白A-1、甘油三酯/高密度脂蛋白胆固醇与老年女性H型高血压的关系  

Relationship between serum uric acid,apolipoprotein A-1,triglyceride/high density lipoprotein-cholesterol and H type hypertension in elderly women

作　　者：边卫 BIAN Wei(Zibo Municipal Government Hospital,Shandong Province,Zibo 255000,China)

机构地区：[1]山东省淄博市市级机关医院,山东淄博255000

出　　处：《妇儿健康导刊》2024年第12期30-33,共4页JOURNAL OF WOMEN AND CHILDREN'S HEALTH GUIDE

摘　　要：目的分析血尿酸、载脂蛋白A-1(ApoA1)、甘油三酯(TG)/高密度脂蛋白胆固醇(HDL-C)与老年女性H型高血压的关系。方法选取2021年8月至2023年8月山东省淄博市市级机关医院收治的198例H型高血压患者作为观察组,另选同期198例普通高血压患者作为对照组。比较两组血尿酸、ApoA1、TG/HDL-C水平;比较观察组高血压1、2、3级患者的血尿酸、ApoA1、TG/HDL-C水平;采用受试者工作特征(ROC)曲线分析血尿酸、ApoA1、TG/HDL-C单独及联合检测的预测价值。结果观察组血尿酸、TG/HDL-C水平高于对照组,ApoA1水平低于对照组,差异有统计学意义(P<0.05);高血压3级患者血尿酸、TG/HDL-C水平[(389.85±40.15)μmol/L、(1.78±0.28)]高于高血压2级[(328.96±34.25)μmol/L、(1.47±0.26)]、1级[(291.52±30.14)μmol/L、(1.24±0.22)],ApoA1水平[(1.15±0.19)g/L]低于高血压2级[(1.37±0.22)g/L]、1级[(1.48±0.26)g/L](P<0.05),高血压1级患者血尿酸、TG/HDL-C水平低于高血压2级,ApoA1水平高于高血压2级(P<0.05);ROC曲线分析结合显示,联合检测的曲线下面积(0.934)高于血尿酸、ApoA1、TG/HDL-C单独检测(0.811、0.728、0.825)。结论血尿酸、ApoA1、TG/HDL-C与老年女性H型高血压病情严重程度关系密切,且联合检测预测价值较高。Objective To analyze the relationship between serum uric acid,apolipoprotein A-1(ApoA1),triglyceride(TG)/high density lipoprotein-cholesterol(HDL-C)and H type hypertension in elderly women.Methods A total of 198 patients with H type hypertension admitted to Zibo Municipal Government Hospital of Shandong Province from August 2021 to August 2023 were selected as the observation group,and 198 patients with common hypertension during the same period were selected as the control group.The levels of serum uric acid,ApoA1,and TG/HDL-C were compared between the two groups.The levels of serum uric acid,ApoA1,and TG/HDL-C in patients with grade 1,2,and 3 hypertension in the observation group were compared.The predictive value of serum uric acid,ApoA1,and TG/HDL-C alone and in combination was analyzed by receiver operating characteristic(ROC)curve.Results The levels of serum uric acid and TG/HDL-C in the observation group were higher than those in the control group,and the level of ApoA1 was lower than that in the control group,and the differences were statistically significant(P<0.05).The levels of serum uric acid and TG/HDL-C in patients with grade 3 hypertension([389.85±40.15]μmol/L,[1.78±0.28])were higher than those in patients with grade 2 hypertension([328.96±34.25]μmol/L,[1.47±0.26])and grade 1 hypertension([291.52±30.14]μmol/L,[1.24±0.22]).The level of ApoA1([1.15±0.19]g/L)was lower than that of hypertension grade 2([1.37±0.22]g/L)and hypertension grade 1([1.48±0.26]g/L)(P<0.05).The levels of serum uric acid and TG/HDL-C in patients with grade 1 hypertension were lower than those in patients with grade 2 hypertension,and the level of ApoA1 was higher than that of grade 2 hypertension(P<0.05).ROC curve analysis showed that the area under the curve of combined detection(0.934)was higher than that of serum uric acid,ApoA1,TG/HDL-C(0.811,0.728,0.825).Conclusion Serum uric acid,ApoA1 and TG/HDL-C are closely related to the severity of H type hypertension in elderly women,and the combined detection has a high

关 键 词：H型高血压 血尿酸 载脂蛋白A-1 甘油三酯 高密度脂蛋白胆固醇 

分 类 号：R446[医药卫生—诊断学]