中西医治疗对糖尿病性溃疡炎性因子的调节作用  

Regulating Effect of Traditional Chinese and Western Medicine on Inflammatory Factors of Diabetic Ulcers

作　　者：陈蕾 李大勇[2] CHEN Lei;LI Dayong(Liaoning University of Traditional Chinese Medicine,Shenyang 110847,Liaoning,China;Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110032,Liaoning,China)

机构地区：[1]辽宁中医药大学,辽宁沈阳110847 [2]辽宁中医药大学附属医院,辽宁沈阳110032

出　　处：《辽宁中医药大学学报》2024年第7期136-140,共5页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：国家重大科技专项(2019YFC1709303)。

摘　　要：糖尿病性溃疡(DUs)是众所周知的糖尿病破坏性并发症,是最普遍的慢性伤口类型之一,它们是导致下肢截肢的常见原因,病死率较高。中医对于治疗糖尿病性溃疡有一定的特色与优势,能够使全身和局部症状得到改善,加速溃疡愈合,具有较好的临床效果,现代医学研究发现,糖尿病性溃疡难以愈合与炎性反应密切相关,随着研究不断进展发现,除了中药单体、复方制剂,现代医学新型生物疗法对炎性反应的调控亦逐渐成为该病的研究热点,文章对中医药及现代医学的研究进行了归纳,得出以下结论:①积雪草苷、黄芪多糖、银杏叶提取物、蜂蜜及黄连紫草湿性敷料、解毒生肌膏、紫朱软膏等,通过调控肿瘤坏死因子α(TNF-α)、白细胞介素1β(IL-1β)、白细胞介素6(IL-6)等因子抑制炎症反应。②新型生物疗法自体富血小板血浆、干细胞疗法、纳米技术等,通过调控肿瘤坏死因子α(TNF-α)、白细胞介素1β(IL-1β)等因子,同时影响巨噬细胞(M1、M2型)等因子抑制炎症反应。③中药单体、复方制剂及新型生物疗法皆通过抑制炎症反应的作用机制治疗糖尿病性溃疡,可进行深入探讨。以上结论旨在为今后从炎症反应角度治疗糖尿病性溃疡提供思路。Diabetic ulcers(DUs)are well known as a devastating complication of diabetes and are one of the most prevalent types of chronic wounds;they are a common cause of lower limb amputations and have a high mortality rate.Chinese medicine has certain characteristics and advantages for the treatment of diabetic ulcers,which can improve systemic and local symptoms and accelerate ulcer healing with better clinical effects.Modern medical research has found that the difficulty in healing diabetic ulcers is closely related to the inflammatory response,and as research continues to progress it has been found that,in addition to the monomeric and compound preparations of Chinese medicine,the modulation of the inflammatory response by the new biological therapies of modern medicine is gradually becoming This paper summarizes the research on TCM and modern medicine,and draws the following conclusions:①Asiaticoside,Astragalus polysaccharide,Ginkgo biloba leaf extract,honey and Huanglian Zicao Wet Dressing,Jiedu Shengji Ointment(解毒生肌膏),Zizhu Ointment(紫朱软膏),etc.inhibit the inflammatory response by regulating factors such as tumour necrosis factor-α(TNF-α),interleukin-1β(IL-1β)and interleukin-6(IL-6).②New biological therapies such as autologous platelet-rich plasma,stem cell therapy and nanotechnology inhibit the inflammatory response by regulating factors such as tumour necrosis factor-α(TNF-α)and interleukin-1β(IL-1β),while affecting factors such as macrophages(M1 and M2 types)factors.③Chinese herbal monomers,compound preparations and novel biologic therapies all act through mechanisms that inhibit the inflammatory response in the treatment of diabetic ulcers and can be explored in depth.The above conclusions aim to provide ideas for the future treatment of diabetic ulcers from the perspective of inflammatory response.

关 键 词：糖尿病性溃疡 炎性反应 中医治疗 西医治疗 

分 类 号：R259[医药卫生—中西医结合]