NF-κB信号通路在卒中后认知障碍中的作用及中药干预的研究进展  被引量:2

Role of the NF-κB Signaling Pathway in Post-Stroke Cognitive Impairment and Current Research Progress on Traditional Chinese Medicine Interventions

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作  者:陈义汝 郝顺发 钱仁义[2] 关运祥[2] CHEN Yiru;HAO Shunfa;QIAN Renyi;GUAN Yunxiang(Henan University of Chinese Medicine,Zhengzhou 450046,Henan,China;The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,Henan,China)

机构地区:[1]河南中医药大学,河南郑州450046 [2]河南中医药大学第一附属医院,河南郑州450000

出  处:《辽宁中医药大学学报》2024年第7期197-203,共7页Journal of Liaoning University of Traditional Chinese Medicine

基  金:河南省中医药科学研究专项(2018ZY2073)。

摘  要:卒中后认知障碍(post-stroke cognitive impairment,PSCI)是卒中事件引起认知损害的一类临床综合征,严重影响卒中后患者的预后及生存质量。核因子-κB(nuclear factor-κB,NF-κB)信号通路在PSCI中能够参与炎症反应、氧化应激、细胞凋亡、血管生成等过程,对PSCI的发生发展及预后至关重要。近年来,诸多研究发现NF-κB信号通路是中医药防治PSCI的重要潜在靶点,黄酮类、皂苷类、萜类等中药成分及补阳还五汤、圣愈汤、安宫牛黄丸等中药复方可通过抑制NF-κB信号通路来改善炎症反应、抑制氧化应激以及抗细胞凋亡等,从而改善卒中后患者的认知功能,然而,针对NF-κB信号通路在PSCI中的作用缺乏系统、客观地总结与评价。文章基于NF-κB信号通路,对中药提取物及中药复方防治PSCI的相关机制进行梳理总结,以期为中医药防治PSCI提供新的治疗思路。Post-stroke cognitive impairment(PSCI)is a class of clinical syndromes in which cognitive impairment is caused by stroke events,which seriously affects the prognosis and survival quality of poststroke patients.The nuclear factor-κB(NF-κB)signaling pathway can participate in inflammatory response,oxidative stress,apoptosis,angiogenesis,and other processes in PSCI,which is crucial for the development and prognosis of PSCI.In recent years,many studies have found that the NF-κB signaling pathway is an important potential target for the prevention and treatment of PSCI in traditional Chinese medicine(TCM).Traditional Chinese medicines(TCM)components such as flavonoids,saponins,terpenoids,and TCM compound formulas such as tonifying yang and restoring wu tang,sheng gui tang,and anglo niu huangwan,etc.,can improve inflammatory reactions,inhibit oxidative stress,and resist apoptosis through the inhibition of NF-κB signaling,and thereby improve the cognitive function of post-stroke patients.However,there is a lack of systematic and objective summary and evaluation of the role of the NF-κB signaling pathway in PSCI.In this paper,we summarize the mechanisms of Chinese herbal extracts and Chinese herbal compounds in the prevention and treatment of PSCI based on the NF-κB signaling pathway,with the aim of providing new therapeutic ideas for the prevention and treatment of PSCI with Chinese medicine.

关 键 词:脑卒中 认知障碍 卒中后认知障碍 核因子-ΚB信号通路 炎症反应 

分 类 号:R285[医药卫生—中药学]

 

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