经典型单核细胞亚群百分比、SYNTAX Ⅰ积分对急性心肌梗死患者PCI后预后的预测价值  

Predictive Value of Classical Monocytes Percentage and SYNTAXⅠScore for the Prognosis of Patients with Acute Myocardial Infarction after PCI

作　　者：帕丽达·玉山江 吾麦尔江·克力木 尼格热·阿力木 吐尔孙阿依·依斯提米拉 马艺萍 穆叶赛·尼加提[1] PALIDA·Yushanjiang;WUMAIERJIANG·Kelimu;NIGERE·Alimu;TUERSUNAYI·Yisitimila;MA Yiping;MUYESAI·Nijiati(Department of Emergency,People's Hospital of Xinjiang Uygur Autonomous Region,Urumqi 830011,China;Department of Cardiology,Kashgar District Second People's Hospital,Kashgar 844099,China;Graduate Student Court,Xinjiang Medical University,Urumqi 830054,China)

机构地区：[1]新疆维吾尔自治区人民医院急救中心,新疆维吾尔自治区乌鲁木齐市830011 [2]喀什地区第二人民医院心内科,新疆维吾尔自治区喀什市844099 [3]新疆医科大学研究生学院,新疆维吾尔自治区乌鲁木齐市830054

出　　处：《实用心脑肺血管病杂志》2024年第7期16-20,25,共6页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

基　　金：国家自然科学基金资助项目(82060076);新疆维吾尔自治区自然科学基金地州科学基金项目(2021D01F18)。

摘　　要：目的分析经典型单核细胞亚群(Mon1)百分比、SYNTAXⅠ积分对急性心肌梗死(AMI)患者PCI后预后的预测价值。方法回顾性选取2021年3月—2022年6月于新疆维吾尔自治区人民医院心内科和喀什地区第二人民医院心内科行PCI的AMI患者100例为研究对象。根据术后1年主要不良心血管事件(MACE)发生情况,将患者分为MACE组(14例)和非MACE组(86例)。收集患者的临床资料,采用单因素、多因素Logistic回归分析探讨AMI患者PCI后发生MACE的影响因素;采用ROC曲线分析Mon1百分比、SYNTAXⅠ积分对AMI患者PCI后发生MACE的预测价值。结果MACE组Mon1百分比、SYNTAXⅠ积分高于非MACE组(P<0.05)。单因素Logistic回归分析结果显示,Mon1百分比、SYNTAXⅠ积分可能是AMI患者PCI后发生MACE的影响因素(P<0.05);多因素Logistic回归分析结果显示,Mon1百分比、SYNTAXⅠ积分是AMI患者PCI后发生MACE的独立影响因素(P<0.05)。ROC曲线分析结果显示,Mon1百分比、SYNTAXⅠ积分预测AMI患者PCI后发生MACE的AUC分别为0.880〔95%CI(0.812~0.947)〕、0.796〔95%CI(0.674~0.918)〕,最佳截断值分别为54.5%、26.8分,灵敏度分别为92.9%、64.3%,特异度分别为74.4%、82.6%;Mon1百分比联合SYNTAXⅠ积分预测AMI患者PCI后发生MACE的AUC为0.906〔95%CI(0.841~0.972)〕,灵敏度为93.0%,特异度为76.7%。结论Mon1百分比、SYNTAXⅠ积分是AMI患者PCI后发生MACE的独立影响因素;Mon1百分比、SYNTAXⅠ积分均对AMI患者PCI后发生MACE有一定预测价值,且二者联合的预测价值更高。Objective To analyze the predictive value of classical monocytes(Mon1)percentage and SYNTAXⅠscore for the prognosis of patients with acute myocardial infarction(AMI)after PCI.Methods A total of 100 patients with AMI who underwent PCI in the Department of Cardiology of People's Hospital of Xinjiang Uygur Autonomous Region and Department of Cardiology of Kashgar District Second People's Hospital from March 2021 to June 2022 were retrospectively selected as the study objects.According to the occurrence of major adverse cardiovascular events(MACE)1 year after surgery,the patients were divided into MACE group(14 cases)and non-MACE group(86 cases).The clinical data of patients were collected.Univariate and multivariate Logistic regression analysis was used to investigate the influencing factors of MACE in AMI patients after PCI.ROC curve was used to analyze the predictive value of Mon1 percentage and SYNTAXⅠscore for MACE in AMI patients after PCI.Results The Mon1 percentage and SYNTAXⅠscore in MACE group were higher than those in non-MACE group(P<0.05).The results of univariate Logistic regression analysis showed that Mon1 percentage and SYNTAXⅠscore may be the influencing factors of MACE in AMI patients after PCI(P<0.05).Multivariate Logistic regression analysis showed that Mon1 percentage and SYNTAXⅠscore were independent influencing factors for MACE in AMI patients after PCI(P<0.05).ROC curve analysis results showed that the AUC of Mon1 percentage and SYNTAXⅠscore in predicting MACE in AMI patients after PCI was 0.880[95%CI(0.812-0.947)]and 0.796[95%CI(0.674-0.918)],the optimal cut-off value was 54.5%and 26.8,the sensitivity was 92.9%and 64.3%,and the specificity was 74.4%and 82.6%,respectively.The AUC of Mon1 percentage combined with SYNTAXⅠscore in predicting MACE in AMI patients after PCI was 0.906[95%CI(0.841-0.972)],with a sensitivity of 93.0%and a specificity of 76.7%.Conclusion Mon1 percentage and SYNTAXⅠscore are independent influencing factors for MACE in AMI patients after PCI.Both Mon1 pe

关 键 词：心肌梗死 单核细胞 经典型单核细胞亚群 SYNTAXⅠ积分 经皮冠状动脉介入治疗 预后 

分 类 号：R542.22[医药卫生—心血管疾病]