心力衰竭与焦虑症的因果关系:两样本孟德尔随机化分析  

Causal Relationship between Heart Failure and Anxiety Disorders:a Two-Sample Mendelian Randomization Analysis

作　　者：常博南 崔文竹[2] 赵明禄 刘洋 王菁华[2] CHANG Bonan;CUI Wenzhu;ZHAO Minglu;LIU Yang;WANG Jinghua(The First Clinical Medical College to Shandong University of Traditional Chinese Medicine,Ji'nan 250014,China;Department of Cardiology,the Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Ji'nan 250001,China)

机构地区：[1]山东中医药大学第一临床医学院,山东省济南市250014 [2]山东中医药大学第二附属医院心血管病科,山东省济南市250001

出　　处：《实用心脑肺血管病杂志》2024年第7期31-35,共5页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

基　　金：山东省中医药科技发展计划青年项目(2021Q105)。

摘　　要：目的 采用两样本孟德尔随机化(TSMR)分析方法探讨心力衰竭(HF)与焦虑症的因果关系。方法 HF的全基因组关联研究(GWAS)数据来自FinnGen数据库,其样本量为218 208例,单核苷酸多态性(SNP)数量为16 380 447个;焦虑症的GWAS数据来自GWAS Catalog数据库,其样本量为502 474例,SNP数量为7 749 106个。筛选与HF高度相关的SNP作为工具变量。本研究主要采用逆方差加权法(IVW)分析HF与焦虑症的因果关系,同时采用MR-Egger回归、加权中位数法(WM)对IVW分析结果进行补充;采用Cochran's Q检验判断SNP间的统计学异质性,采用MR-Egger回归的截距项评估SNP是否存在水平多效性,采用留一法评估单个SNP对IVW分析结果的影响。结果 本研究共筛选出39个与HF高度相关的SNP,剔除10个与焦虑症GWAS数据不匹配的SNP后,最终纳入29个与HF高度相关的SNP。IVW分析结果显示,HF会增加焦虑症的发病风险〔OR=1.004,95%CI(1.001~1.007),P=0.013〕;虽然MR-Egger回归、WM分析结果显示,HF不会增加焦虑症发病风险(P>0.05),但其β值与IVW的β值方向一致。Cochran's Q检验分析结果显示,与HF高度相关的SNP间不存在统计学异质性(Q=33.012,P=0.235);MR-Egger回归的截距项分析结果显示,与HF高度相关的SNP不存在水平多效性(P=0.524);留一法分析结果显示,剔除单个SNP后,IVW分析结果无明显改变。结论 HF会增加焦虑症的发病风险。Objective To explore the causal relationship between heart failure(HF)and anxiety disorders by two-sample Mendelian randomization(TSMR)analysis method.Methods The genome-wide association study(GWAS)data of HF was obtained from the FinnGen database,its sample size was 218208,and the number of single nucleotide polymorphisms(SNP)was 16380447.The GWAS data of anxiety disorder was from the GWAS Catalog database,its sample size was 502474 and the number of SNP was 7749106.SNP highly associated with HF were screened as instrumental variables.In this study,inverse variance weighting(IVW)was used to analyze the causal relationship between HF and anxiety disorders,and MR-Egger regression and weighted median(WM)were used to supplement the results of IVW.Cochran'sQtest was used to determine the statistical heterogeneity among SNPs.The intercept term of MR-Egger regression was used to evaluate whether there was horizontal pleiotropy in SNP.The effect of single SNP on IVW results was evaluated by leave-one-out method.Results A total of 39 SNPs highly associated with HF were screened in this study.After excluding 10 SNPs those did not match the GWAS data of anxiety disorder,29 SNPs highly associated with HF were finally included.The results of IVW analysis showed that HF increased the risk of anxiety disorders[OR=1.004,95%CI(1.001-1.007),P=0.013].Although the results of MR-Egger regression and WM analysis showed that HF did not increase the risk of anxiety disorders(P>0.05),theirβvalues were consistent with theβvalue of IVW.Cochran'sQtest showed that there was no statistical heterogeneity among SNPs highly associated with HF(Q=33.012,P=0.235).The intercept term of MR-Egger regression analysis showed that there was no horizontal pleiotropy in SNPs highly correlated with HF(P=0.524).The results of leave-one-out analysis showed that after excluding a single SNP,the results of IVW analysis did not change significantly.Conclusion HF can increases the risk of anxiety disorders.

关 键 词：心力衰竭 焦虑症 孟德尔随机化分析 因果关系 

分 类 号：R541.62[医药卫生—心血管疾病] R749.72[医药卫生—内科学]