可溶性生长刺激表达基因2蛋白与高血压左心室肥大的关系  

Relationship between Soluble Uppression of Tumorigenicity 2 and Hypertensive Left Ventricular Hypertrophy

作　　者：谢云梯 潘兴寿[1] XIE Yunti;PAN Xingshou(Department of Cardiology,Affiliated Hospital of Youjiang Medical University for Nationalities,Baise 533000,China;Graduate School,Youjiang Medical University for Nationalities,Baise 533000,China)

机构地区：[1]右江民族医学院附属医院心血管内科,广西壮族自治区百色市533000 [2]右江民族医学院研究生学院,广西壮族自治区百色市533000

出　　处：《实用心脑肺血管病杂志》2024年第7期130-134,共5页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

基　　金：广西自然科学基金项目(2019JJA140159)。

摘　　要：可溶性生长刺激表达基因2蛋白(sST2)是白介素1受体家族成员,与心肌纤维化密切相关,而心肌纤维化是高血压左心室肥大(LVH)的重要组成部分。近年研究发现,sST2在高血压LVH发生发展中发挥着重要作用。本文通过分析sST2与高血压LVH的关系发现,sST2是高血压LVH的生物标志物,其主要通过心肌纤维化导致高血压LVH。Soluble suppression of tumorigenicity 2(sST2)is a member of the interleukin-1 receptor family and is closely related to myocardial fibrosis,which is an important component of hypertensive left ventricular hypertrophy(LVH).Recent studies have found that sST2 plays an important role in the development of hypertensive LVH.In this paper,by analyzing the relationship between sST2 and hypertensive LVH,it is found that sST2 is a biomarker of hypertensive LVH,which mainly leads to hypertensive LVH through myocardial fibrosis.

关 键 词：高血压 左心室肥大 可溶性生长刺激表达基因2蛋白 综述 

分 类 号：R544.1[医药卫生—心血管疾病]