葛根素治疗心肌缺血再灌注损伤的机制研究进展  

Research Progress on the Mechanism of Puerarin in the Treatment of Myocardial Ischemia-Reperfusion Injury

作　　者：郑小宇 王威 ZHENG Xiaoyu;WANG Wei(School of Clinical Medicine,Chongqing Medical and Pharmaceutical College,Chongqing 401331,China;Department of Orthopedics,People's Hospital of Chongqing Yubei District,Chongqing 401120,China)

机构地区：[1]重庆医药高等专科学校临床学院,重庆市401331 [2]重庆市渝北区人民医院骨科,401120

出　　处：《实用心脑肺血管病杂志》2024年第7期135-140,共6页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

基　　金：重庆市自然科学基金面上项目(cstc2021jcyj-msxmX0704);重庆市教委科学技术研究计划项目(KJQN202302833)。

摘　　要：心肌缺血再灌注损伤(MIRI)是冠状动脉血运重建时不可避免的并发症,目前尚缺乏有效的治疗方案。MIRI的发生机制除涉及氧化应激、炎症反应外,不同类型的程序性细胞死亡也被证实参与其中。葛根素作为从传统中药提取的衍生物,在抗炎、抗氧化、抗心肌肥厚和心肌纤维化等方面发挥积极作用,与程序性细胞死亡也有着紧密联系。本研究总结了葛根素的心血管保护效应及其治疗MIRI的机制,剖析了葛根素在MIRI中的作用靶点,以期为MIRI的有效治疗策略提供新的方向和思路。Myocardial ischemia reperfusion injury(MIRI)is an inevitable complication of coronary revascularization.Recently,there is a lack of effective treatment for MIRI.In addition to oxidative stress and inflammation,different types of programmed cell death have also been confirmed to be involved in the development of MIRI.Puerarin,as a derivative extracted from traditional Chinese medicine,plays an positive role in anti-inflammatory,antioxidant,anti-myocardial hypertrophy and myocardial fibrosis,which is closely related to programmed cell death.This study summarizes the cardiovascular protective effect of puerarin and its mechanism in treating MIRI,analyzes the targets of puerarin in MIRI,providing a new direction and thinking for effective treatment strategies of MIRI.

关 键 词：心肌缺血再灌注损伤 葛根素 氧化性应激 综述 

分 类 号：R542.2[医药卫生—心血管疾病]