血清cMyBP-C对急性心肌梗死早期的诊断价值  

Serum cMyBP-C value to the diagnosis of early of acute myocardial infarction

作　　者：李云豪 李菁[1] 彭欢子 许莹芊 王金全 彭嘉琪 谢小兵[1] LI Yunhao;LI Jing;PENG Huanzi;XU Yingqian;WANG Jinquan;PENG Jiaqi;XIE Xiaobing(Laboratory Medicine Center,the First Affiliated Hospital of Hunan University of Traditional Chinese Medicine,Changsha,Hunan 410007,China)

机构地区：[1]湖南中医药大学第一附属医院医学检验中心,湖南长沙410007

出　　处：《检验医学与临床》2024年第13期1851-1854,共4页Laboratory Medicine and Clinic

基　　金：湖南省卫生健康委科研课题(202211003853);湖南省科技厅重点领域研发计划-重点研发(2022GK2057);湖南中医药大学学科建设“揭榜挂帅”项目(22JBZ037)。

摘　　要：目的探讨血清心肌肌球蛋白结合蛋白C(cMyBP-C)对急性心肌梗死(AMI)早期的诊断价值。方法选取2022年1月至2023年1月该院收治的90例AMI患者作为观察组。另选取该院同期收治的90例非AMI患者作为对照组。检测并比较两组cMyBP-C、血清肌酸激酶同工酶(CK-MB)、肌红蛋白(Myo)、超敏心肌肌钙蛋白T(hscTnT)水平,分析AMI患者血清cMyBP-C水平与CK-MB、Myo、hscTnT水平的相关性。绘制受试者工作特征(ROC)曲线分析血清cMyBP-C、CK-MB、Myo、hscTnT单独及cMyBP-C与hscTnT联合检测对AMI早期的诊断价值。采用Spearman相关分析AMI患者血清cMyBP-C水平与CK-MB、Myo、hscTnT水平的相关性。结果观察组血清cMyBP-C、CK-MB、Myo、hscTnT水平均高于对照组(P<0.05)。ROC曲线分析结果显示,血清cMyBP-C、CK-MB、Myo、hscTnT单独及cMyBP-C与hscTnT联合检测诊断AMI的曲线下面积(AUC)分别为0.96、0.76、0.81、0.95、0.98,血清cMyBP-C、CK-MB、Myo、hscTnT单独检测的AUC均低于cMyBP-C与hscTnT联合检测的AUC(P<0.05)。Spearman相关分析结果显示,AMI患者cMyBP-C水平与CK-MB、Myo水平均呈正相关(r=0.381、0.409,P<0.05),与hscTnT水平无相关性(r=0.062,P>0.05)。结论血清cMyBP-C、CK-MB、Myo、hscTnT 4项指标均可作为AMI发生早期的诊断指标,cMyBP-C与hscTnT联合检测诊断AMI的价值优于上述4项指标单独检测。cMyBP-C在AMI早期诊断中具有重要价值,可作为临床诊断早期AMI的重要指标之一。Objective To investigate the value of serum cardiac myosin binding protein C(cMyBP-C)in the early diagnosis of acute myocardial infarction(AMI).Methods A total of 90 AMI patients admitted to the hospital from January 2022 to January 2023 were selected as the observation group.In addition,90 non-AMI patients admitted to the hospital during the same period were selected as the control group.The levels of cMyBP-C,serum creatine kinase isoenzyme(CK-MB),myoglobin(Myo)and high-sensitivity cardiac troponin T(hscTnT)were detected and compared between the two groups,and the correlation between serum cMyBP-C level and CK-MB,Myo and hscTnT levels in AMI patients was analyzed.Receiver operating characteristic(ROC)curve was drawn to analyze the value of serum cMyBP-C,CK-MB,Myo,hscTnT alone and cMyBP-C combined with hscTnT in the early diagnosis of AMI.Spearman correlation analysis was used to analyze the correlation between serum cMyBP-C level and CK-MB,Myo,hscTnT levels in AMI patients.Results The levels of serum cMyBP-C,CK-MB,Myo and hscTnT in the observation group were higher than those in the control group(P<0.05).ROC curve analysis results showed that the area under the curve(AUC)of cMyBP-C,CK-MB,Myo,hscTnT alone and cMyBP-C combined with hscTnT in the diagnosis of AMI was 0.96,0.76,0.81,0.95,0.98 respectively.The AUC of serum cMyBP-C,CK-MB,Myo,and hscTnT alone was lower than that of the combined detection of cMyBP-C and hscTnT(P<0.05).Spearman correlation analysis showed that the level of cMyBP-C was positively correlated with the levels of CK-MB and Myo in AMI patients(r=0.381,0.409,P<0.05).There was no correlation between cMyBP-C level and hscTnT level(r=0.062,P>0.05).Conclusion Serum cMyBP-C,CK-MB,Myo and hscTnT can be used as early diagnostic indicators for AMI,and the combined detection of cMyBP-C and hscTnT in the diagnosis of AMI is better than the single detection of the above four indicators.cMyBP-C has an important value in the early diagnosis of AMI,and it can be used as one of the important indicators for th

关 键 词：心肌梗死 心肌肌球蛋白结合蛋白C 早期诊断 超敏心肌肌钙蛋白T 肌红蛋白 

分 类 号：R273[医药卫生—中西医结合] R446.1[医药卫生—中医肿瘤科]