血清髓过氧化物酶与男性代谢综合征的关系  

Relationship between serum myeloperoxidase and male metabolic syndrome

作　　者：李幸 图尔荪古丽·多力坤 王玉玲[1] LI Xing;Tursun Guri DORIKUN;WANG Yuling(Cadres Healthcare Center,the First Affiliated Hospital of Xinjiang Medical University,Urumqi,Xinjiang Uygur Autonomous Region 830000,China)

机构地区：[1]新疆医科大学第一附属医院干部保健中心,新疆维吾尔自治区乌鲁木齐830000

出　　处：《中华实用诊断与治疗杂志》2024年第6期589-594,共6页Journal of Chinese Practical Diagnosis and Therapy

基　　金：新疆维吾尔自治区区域协同创新专项项目(2021E02068)。

摘　　要：目的 观察男性代谢综合征(MS)患者血清髓过氧化物酶(MPO)水平变化,探讨其对男性发生MS的预测价值。方法 2023年2—4月新疆医科大学第一附属医院男性体检者811例,采用胶体金法检测血清MPO水平,根据是否为MS分为MS组458例和非MS组353例,比较2组年龄、高血压病史、血清MPO水平等临床资料;采用多因素logistic回归分析男性发生MS的影响因素,采用限制性立方样条图分析血清MPO水平与MS的剂量-反应关系;绘制ROC曲线,评估血清MPO预测男性发生MS的效能。结果 MS组年龄[63.0(58.0,68.0)岁]大于非MS组[60.0(56.0,65.0)岁](U=193.063,P<0.001),有高血压、冠心病、糖尿病病史及使用降压药、降糖药比率(81.9%、26.6%、41.7%、42.1%、26.4%),体质量指数[26.6(24.8, 28.5)kg/m^(2)]、腰围[96.0(92.0, 102.0)cm]、收缩压[137.0(128.0,148.0)mmHg]、舒张压[83.0(76.0, 90.0)mmHg]、白细胞计数[6.47(5.50, 7.52)×10^(9)/L]、中性粒细胞计数[3.61(2.87, 4.36)×10^(9)/L]、淋巴细胞计数[2.07(1.69, 2.53)×10^(9)/L]及血清MPO[85.5(75.0, 97.8)μg/L]、空腹血糖[5.81(5.21, 6.80)mmol/L]、糖化血红蛋白[6.14(5.64, 6.74)%]、白蛋白[45.4(43.9, 46.8)g/L]、三酰甘油[1.81(1.30, 2.38)mmol/L]水平均高于非MS组[50.7%、16.7%、5.1%、22.7%、4.8%、25.5(24.2, 27.6)kg/m^(2)、94.0(89.0, 98.0)cm、128.0(120.0, 139.0)mmHg、80.0(73.0, 86.0)mmHg、5.74(4.92, 6.84)×10^(9)/L、3.08(2.51, 3.81)×10^(9)/L、2.00(1.67, 2.40)×10^(9)/L、77.0(67.0, 90.0)μg/L、4.96(4.63, 5.23)mmol/L、5.52(5.30, 5.82)%、44.8(43.1, 46.3)g/L、1.19(0.92,1.46)mmol/L](P<0.05),估算肾小球滤过率[95.1(87.4, 102.0)%]及总胆固醇[4.27(3.48, 5.06)mmol/L]、高密度脂蛋白胆固醇[1.10(0.97, 1.26)mmol/L]、低密度脂蛋白胆固醇[2.78(2.15, 3.38)mmol/L]水平均低于非MS组[98.1(91.3, 103.0)%、4.48(3.84, 5.11)mmol/L、1.25(1.13, 1.41)mmol/L、2.96(2.43, 3.46)mmol/L](P<0.05),民族、吸烟史、饮酒史、红细胞计数、总胆红素水平与非MS组比较差异均无统Objective To observe the changes of serum myeloperoxidase(MPO)in male patients with metabolic syndrome(MS),and to investigate its predictive value.Methods Totally 811 male patients received physical examination in the First Affiliated Hospital of Xinjiang Medical University from February to April,2023,and were divided into MS group(n=458)and non-MS group(n=353).The serum MPO level was detected by colloidal gold method.The general clinical data as age,hypertension history and serum MPO level were compared between two groups.Multivariate logistic regression analysis was done to assess the influencing factors of MS in male patients.Restricted cubic spline plots were used to analyze the dose-response relationship between MPO and MS.ROC curve was plotted to evaluate the efficiency of MPO on predicting MS.Results The patients were older in MS group[63.0(58.0,68.0)years]than non-MS group[60.0(56.0,65.0)years](U=193.063,P<0.001),the proportions of hypertension history,coronary artery disease,diabetes,use of antihypertensive drugs,use of antihyperglycaemic drugs,body mass index,waist circumference,systolic blood pressure,diastolic blood pressure,white blood cell count,neutrophil count,lymphocyte count,and serum levels of MPO,fasting plasma glucose,glycosylated hemoglobin,albumin and triacylglycerol were higher in MS group[81.9%,26.6%,41.7%,42.1%,26.4%,26.6(24.8,28.5)kg/m^(2),96.0(92.0,102.0)cm,137.0(128.0,148.0)mmHg,83.0(76.0,90.0)mmHg,6.47(5.50,7.52)×10^(9)/L,3.61(2.87,4.36)×10^(9)/L,2.07(1.69,2.53)×10^(9)/L,85.5(75.0,97.8)μg/L,5.81(5.21,6.80)mmol/L,6.14(5.64,6.74)%,45.4(43.9,46.8)g/L,1.81(1.30,2.38)mmol/L]than those in non-MS group[50.7%,16.7%,5.1%,22.7%,4.8%,25.5(24.2,27.6)kg/m^(2).94.0(89.0,98.0)cm,128.0(120.0,139.0)mmHg,80.0(73.0,86.0)mmHg,5.74(4.92,6.84)×10^(9)/L,3.08(2.51,3.81)×10^(9)/L,2.00(1.67,2.40)×10^(9)/L,77.0(67.0,90.0)μg/L,4.96(4.63,5.23)mmol/L.5.52(5.30,5.82)%,44.8(43.1,46.3)g/L,1.19(0.92,1.46)mmol/L](P<0.05),the estimated glomerular filtration rate,total cholesterol,high-density lipoprotein choles

关 键 词：代谢综合征 髓过氧化物酶 男性 

分 类 号：R589[医药卫生—内分泌]