基于可植入电极的活体脑化学电分析研究进展  

Advancements of in vivo brain chemical electroanalysis based on implantable electrodes

作　　者：孔凡镇 何瑞煜 顾超越 林雨青[1] KONG Fanzhen;HE Ruiyu;GU Chaoyue;LIN Yuqing(Department of Chemistry,Capital Normal University,Beijing 100048)

机构地区：[1]首都师范大学化学系,北京100048

出　　处：《首都师范大学学报（自然科学版）》2024年第3期74-86,共13页Journal of Capital Normal University：Natural Science Edition

基　　金：国家自然科学基金项目(22104095,22074095,22374103);北京市自然科学基金面上项目(2222005)。

摘　　要：基于可植入电极的活体电化学传感研究一直是推动脑神经化学领域分析方法发展的重要助力。脑内结构的复杂性和各项生理活动的实时性对分析方法提出了严苛的要求。分析测量方法的高特异性、高灵敏度、较强的抗干扰能力以及良好的生物相容性是活体原位分析的前提。随着新功能材料的研发和电化学研究方法的进步,可植入电极的活体电化学研究得到了一定的发展,但该领域仍然存在着一系列的挑战。本文综述了目前可植入电极,如酶修饰电极、核酸适配体修饰电极、离子选择性电极、基于液-液界面的电极、离子电流整流类电极在活体电化学传感领域中的应用以及其兼容性、响应性等关键性能研究的主要进展,以期为未来的复杂脑内环境下的精准检测研究提供有益借鉴。Implantable electrode-based in vivo electrochemical sensing research has consistently played a pivotal role in driving advancements in analytical methods within the field of neurochemical research.The intricacies of brain structures and the real-time nature of various physiological activities impose rigorous demands on analytical approaches.High specificity,elevated sensitivity,robust interference resistance,and favorable biocompatibility are essential prerequisites for in situ analysis in living systems.With the development of novel functional materials and advancements in electrochemical research methodologies,there has been significant progress in the field of in vivo electrochemical analysis employing implantable electrodes.Nonetheless,this field continues to encounter a series of challenges.This article reviews the current applications of implantable electrodes,such as enzymemodified electrodes,aptamer-modified electrodes,ion-selective electrodes,liquid-liquid interface-based electrodes,and ion current rectifying electrodes in the field of in vivo electrochemical sensing,as well as the major progress in the research of their key properties such as biocompatibility and sensitivity.The intention is to offer valuable insights for future research in precision detection within the intricate environment of the brain.

关 键 词：活体电化学传感 可植入电极 脑神经化学 活体原位分析 

分 类 号：O657[理学—分析化学]