胎儿侧脑室增宽孕妇妊娠结局的影响因素分析  

Analysis of influencing factors of pregnancy outcome in pregnant women with fetal ventriculomegaly

作　　者：马翠[1] 代天怡 杨晓月 山丹[1] 刘静[1] Ma Cui;Dai Tianyi;Yang Xiaoyue;Shan Dan;Liu Jing(Department of Obstetrics,Beijing Obstetrics and Gynecology Hospital,Capital Medical University,Beijing Maternal and Child Health Care Hospital,Beijing 100026,China)

机构地区：[1]首都医科大学附属北京妇产医院/北京妇幼保健院产科,100026

出　　处：《北京医学》2024年第4期272-276,共5页Beijing Medical Journal

基　　金：国家自然科学基金(51673119)。

摘　　要：目的探讨胎儿侧脑室增宽(ventriculomegaly,VM)孕妇妊娠结局的影响因素。方法选取2016年4月至2021年4月首都医科大学附属北京妇产医院胎儿VM孕妇179例,根据妊娠结局分为继续妊娠组(152例)和引产组(27例),采用多因素logistic回归分析胎儿VM孕妇妊娠结局的影响因素。结果179例孕妇年龄18~45岁,平均(31.8±4.0)岁,诊断孕周11~40周,平均(27.2±5.9)周。76例孕妇行遗传学检查,其中正常61例(80.3%),异常15例(19.7%),其中染色体数目异常1例,染色体结构异常3例,染色体微缺失微重复11例。多因素logistic回归分析结果显示,诊断孕周≤28周(OR=10.742,95%CI:1.329~86.840,P=0.026)、重度VM(OR=76.674,95%CI:11.266~521.805,P<0.010)及非孤立性VM(OR=10.109,95%CI:1.027~84.439,P=0.020)的孕妇容易发生不良妊娠结局。结论诊断孕周≤28周、重度VM及非孤立性VM是导致胎儿VM孕妇不良妊娠结局的危险因素。Objective To explore the influencing factors of pregnancy outcome in pregnant women with fetal ventriculomegaly(VM).Methods A total of 179 pregnant women who terminated pregnancy due to fetal VM in Beijing Obstetrics and Gynecology Hospital,Capital Medical University from April 2016 to April 2021 were selected,and were divided into continued pregnancy group(152 cases)and induced labor group(27 cases)according to the pregnancy outcome.The influencing factors of pregnancy outcome of pregnant women with fetal VM was analyzed by multivariate logistic regression.Results The age of 179 pregnant women ranged from 18 to 45 years,with an average of(31.8±4.0)years,the gestational age was 11 to 40 weeks,with an average of(27.2±5.9)weeks.A total of 76 pregnant women underwent genetic examination,61 cases were normal(80.3%)and 15 cases were abnormal(19.7%),including one case with abnormal chromosome number,three cases with abnormal chromosome structure and 11 cases with microdeletion and microduplication.Multivariate logistic regression analysis showed that pregnant women diagnosed with gestational age≤28 weeks(OR=10.742,95%CI:1.329-86.840,P=0.026),severe VM(OR=76.674,95%CI:11.266-521.805,P<0.010)and non-isolated VM(OR=10.109,95%CI:1.027-84.439,P=0.020)were prone to adverse pregnancy outcomes.Conclusions Diagnostic gestational age≤28 weeks,severe VM and non-isolated VM are the risk factors for adverse pregnancy outcome of pregnant women with fetal VM.

关 键 词：侧脑室增宽 胎儿 孕妇 妊娠结局 影响因素 

分 类 号：R714.5[医药卫生—妇产科学]