金汁调节肠道菌群治疗老年皮肤瘙痒症作用探析  

Effect of Jinzhi on Treatment of Senile Pruritus

作　　者：钟林 刘梦嵩[1,2] 赵思琪 魏波 廖春璐 陈木兰 车宇慧 郭静 ZHONG Lin;LIU Mengsong;ZHAO Siqi;WEI Bo;LIAO Chunlu;CHEN Mulan;CHE Yuhui;GUO Jing(The Affiliated Hospital to Chengdu University of Traditional Chinese Medicine,Chengdu Sichuan China 610072;Chengdu University of Traditional Chinese Medicine,Chengdu Sichuan China 610072)

机构地区：[1]成都中医药大学附属医院,四川成都610072 [2]成都中医药大学,四川成都610072

出　　处：《中医学报》2024年第7期1384-1387,共4页Acta Chinese Medicine

基　　金：国家自然科学基金项目(82074443);四川省中医药管理局项目科学技术研究专项项目(2022CP1423)。

摘　　要：肠道菌群在肠道内的分布被认为始终保持着共生或拮抗关系,从而达到“平衡”的状态,这与中医提出的治疗疾病目标——“以平为期”相契合。老年人肠道菌群的多样性及优势菌种较年轻人都有着显著变化,这种变化可能会打破肠道微生态的平衡,从而导致人体免疫功能失调、性激素水平变化等,引发老年皮肤瘙痒症,而长期反复的瘙痒引起的焦虑抑郁情绪亦会影响肠道菌群。金汁是以健康儿童粪便为原材料制备而成的中药,经过长时间的埋存,其中的菌群早已与粪便及制作时的滤汁不同,古人认为其性大寒,可用于治疗实证发热、天行瘟疾、阳明燥渴、温病发热等证,这可能与金汁中的菌群调节了肠道菌群而发挥治疗作用有关。粪菌移植也是以健康人的粪便作为原材料,通过现代技术移植到患者体内产生治疗作用,这与中医对金汁的运用有着异曲同工之妙。因此,肠道菌群可能作为干预老年皮肤瘙痒症的新靶点。Gut microbiota maintains a symbiotic or antagonistic relationship to achieve a balance,which is consistent with"Yi Ping Wei Qi",the goal of treating diseases proposed by traditional Chinese medicine(TCM).Compared with young people,there are significant changes in the diversity and dominant species of gut microbiota in the elderly,which may break the balance of intestinal microecology,and lead to immune dysfunction,changes in sex hormone levels,thus triggering skin pruritus in the elderly.In turn,the anxiety and depression caused by long-term repetitive pruritus can also affect the gut microbiota.Jinzhi is a traditional Chinese medicine prepared from the feces of healthy children.After long time of buried storage,the microbiota in Jinzhi is quite different from that in the fecal filtrate juice.The ancient people believed that it is extremely Cold in nature and can be used to treat diseases or syndromes such as fever with excess syndrome,pestilent warm diseases or epidemics,dryness and thirst of Yangming and febrile disease,which is possibly related to the fact that the microbiota in the Jinzhi plays a therapeutic role by modulating the gut microbiota.Fecal microbiota transplantation into the body of patients through modern technology also uses the feces of healthy people as raw materials to produce therapeutic effects,which is similar to the application of Jinzhi in TCM.From this prospect,gut microbiota may be a new target for the intervention of senile pruritus.

关 键 词：金汁 老年皮肤瘙痒症 肠道菌群 免疫 性激素 抑郁 焦虑 

分 类 号：R275.9[医药卫生—中西医结合]