祛风活血醒脑汤联合锻炼对高血压脑出血患者术后康复的影响  

Effect of Qufeng Huoxue Xingnao Decoction Combined with Exercise on Postoperative Rehabilitation of Patients with Hypertensive Cerebral Hemorrhage

作　　者：张天华 ZHANG Tianhua(Kaifeng Traditional Chinese Medicine Hospital,Kaifeng Henan China 475000)

机构地区：[1]开封市中医院,河南开封475000

出　　处：《中医学报》2024年第7期1566-1571,共6页Acta Chinese Medicine

基　　金：河南省中医药科学研究专项课题项目(2019ZY3015);开封市科技发展计划项目(2003102)。

摘　　要：目的:观察祛风活血醒脑汤联合锻炼对高血压脑出血患者术后康复的影响。方法:158例高血压脑出血患者随机分为对照组和观察组各79例。两组术后均给予常规康复锻炼,观察组在对照组治疗基础上给予祛风活血醒脑汤。比较两组患者治疗前后脑血流动力学(脑血管平均流量、脑血管平均流速、血管外周阻力)、炎症因子[白细胞介素-6(interleukin-6,IL-6)、白细胞介素-8(interleukin-8,IL-8)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)]水平、美国国立卫生研究院卒中量表(National Institute of Health stroke scale,NIHSS)评分、简易精神状态检查量表(mini-mental state examination,MMSE)评分、Fugl-Meyer运动量表(Fugl-Meyer assessment,FMA)评分、日常生活活动能力(activity of daily living,ADL)评分及临床疗效、不良反应。结果:两组患者治疗后脑血管流量、脑血管流速、血管外周阻力均显著改善,观察组治疗后脑血管流量、脑血管流速、血管外周阻力分别为(13.76±3.68)mL·s^(-1)、(17.65±2.12)cm·s^(-1)、(866.54±92.36)kPa·s·m^(-1),观察组治疗后脑血管流量、脑血管流速高于对照组,血管外周阻力低于对照组,差异均有统计学意义(P<0.05)。观察组治疗后IL-6、IL-8、TNF-α水平为(38.85±8.24)ng·L^(-1)、(31.28±3.25)ng·L^(-1)、(49.21±8.24)ng·L^(-1),观察组低于对照组,差异均有统计学意义(P<0.05)。观察组治疗后NIHSS和MMSE评分分别为(4.86±0.72)分、(27.43±3.20)分,观察组优于对照组,差异有统计学意义(P<0.05)。观察组治疗后FMA和ADL评分分别为(73.65±8.95)分、(69.88±6.26)分,观察组高于对照组,差异有统计学意义(P<0.05)。观察组有效率为93.67%,对照组有效率为78.48%,观察组有效率高于对照组,差异均有统计学意义(P<0.05)。观察组不良反应发生率为6.34%,对照组为0,观察组不良反应发生率高于对照组,差异有统计学意义(P<0.05)。结论:祛风活血醒脑汤联合锻�Objective:To observe the effect of Qufeng Huoxue Xingnao Decoction combined with exercise on postoperative rehabilitation of patients with hypertensive cerebral hemorrhage.Methods:A total of 158 patients with hypertensive cerebral hemorrhage were randomly divided into a control group and an observation group,with 79 cases in each group.Two groups were given routine postoperative rehabilitation exercise,and the observation group was given Qufeng Huoxue Xingnao Decoction additionally based on that of the control group.The cerebral hemodynamics(mean cerebrovascular flow,mean cerebrovascular velocity,peripheral vascular resistance),inflammatory factors[interleukin-6(IL-6),interleukin-8(IL-8),tumor necrosis factor-α(TNF-α)],National Institute of Health stroke scale(NIHSS)score,mini-mental state examination(MMSE)score,Fugl-Meyer assessment(FMA)score and activity of daily living(ADL)score before and after treatment,as well as clinical curative effect and adverse reactions were compared between the two groups.Results:The cerebrovascular flow,cerebrovascular velocity and peripheral vascular resistance of the two groups were significantly improved after treatment.After treatment,the cerebrovascular flow and cerebrovascular velocity of observation group was respectively(13.76±3.68)mL·s^(-1) and(17.65±2.12)cm·s^(-1),higher than that of the control group,while the peripheral vascular resistance of(866.54±92.36)kPa·s·m^(-1) was lower than that of the control group significantly(P<0.05).After treatment,the levels of IL-6,IL-8 and TNF-αin the observation group were(38.85±8.24)ng·L^(-1) and(31.28±3.25)ng·L^(-1),(49.21±8.24)ng·L^(-1) respectively,which were lower than those of the control group,and the differences were statistically significant(P<0.05).After treatment,the NIHSS and MMSE scores of the observation group were(4.86±0.72)points and(27.43±3.20)points,which were better than those of the control group,and the differences were statistically significant(P<0.05).FMA and ADL scores of the observation group a

关 键 词：高血压脑出血 祛风活血醒脑汤 脑血流动力学 炎症因子 认知功能 术后康复 

分 类 号：R259.441[医药卫生—中西医结合]