基于层次分析-逼近理想解排序法的沙库巴曲缬沙坦药物利用评价  

Drug Utilization Evaluation of Sacubitril and Valsartan Based on AHP-TOPSIS Method

作　　者：赵杰 陈康夷 余庆 杨懿[2] 赵云燕[1] 詹三华 ZHAO Jie;CHEN Kangyi;YU Qing;YANG Yi;ZHAO Yunyan;ZHAN Sanhua(Tongling People's Hospital,Tongling,Anhui,China 244000;The First Affiliated Hospital of Anhui Medical University,Hefei,Anhui,China 230031)

机构地区：[1]安徽省铜陵市人民医院,安徽铜陵244000 [2]安徽医科大学第一附属医院,安徽合肥230031

出　　处：《中国药业》2024年第13期15-19,共5页China Pharmaceuticals

基　　金：安徽省公益性技术应用研究联动计划项目[1604f0804041]。

摘　　要：目的评价沙库巴曲缬沙坦临床使用的合理性。方法以沙库巴曲缬沙坦钠片的药品说明书为基础,参考临床指南、专家共识等文献资料,建立沙库巴曲缬沙坦的药物利用评价标准,采用层次分析法(AHP)对评价标准的各项指标进行赋权,通过逼近理想解排序(TOPSIS)法对医院2022年1月至6月使用沙库巴曲缬沙坦的153份病历资料进行合理性评价。结果共建立3个一级指标,10个二级指标。相对权重较高的前3个二级指标分别为适应证、禁忌证、给药剂量及调整,相对权重系数分别为0.2436,0.2436,0.1334。153份病历中,完全合理用药、合理用药、基本合理用药、不合理用药分别占30.07%,7.84%,28.76%,33.33%,不合理用药主要表现为给药剂量及调整不适宜(36.60%)、适应证不适宜(26.80%)、药物相互作用不合理(14.38%)。结论基于AHP-TOPSIS法的沙库巴曲缬沙坦药物利用评价方法切实可行。该院沙库巴曲缬沙坦使用基本合理,但仍存在适应证、用法用量、安全性等方面的问题,需要进一步规范药品的合理使用。Objective To evaluate the rationality of the clinical use of sacubitril and valsartan.Methods Based on the drug instructions of Sacubitril Valsartan Sodium Tablets,referring to clinical guidelines,expert consensus and other literature data,the drug utilization evaluation criterion of sacubitril and valsartan was established.The analytic hierarchy process(AHP)was used to weight various indicators of the evaluation criterion,and the Technique for Order Preference by Similarity to an Ideal Solution(TOPSIS)method was used to evaluate the rationality of 153 medical records containing sacubitril and valsartan in the hospital from January to June 2022.Results Three primary indicators and ten secondary indicators were established.The top three secondary indicators with relatively high relative weights were indications,contraindications,drug dosage and dosage adjustment,with relative weight coefficients of 0.2436,0.2436,and 0.1334,respectively.Among 153 medical records,the completely rational drug use,rational drug use,basically rational drug use,and irrational drug use accounted for 30.07%,7.84%,28.76%,and 33.33%respectively.The main manifestations of irrational drug use were inappropriate dosage adjustment(36.60%),inappropriate indications(26.80%),and irrational drug-drug interactions(14.38%).Conclusion The drug utilization evaluation method of sacubitril and valsartan based on AHP-TOPSIS is feasible.The use of sacubitril and valsartan in the hospital is generally reasonable,but there are still some problems such as indications,usage and dosage,safety,and other aspects,which require further standardization of the rational drug use.

关 键 词：沙库巴曲缬沙坦 层次分析法 逼近理想解排序法 合理性评价 

分 类 号：R95[医药卫生—药学] R972.4