四磨汤口服液联合小儿化食口服液治疗小儿功能性便秘临床观察  

Clinical Observation of Simo Tang Oral Liquid Combined with Xiao′er Huashi Oral Liquid in the Treatment of Functional Constipation in Children

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作  者:刘静 刘鸿敏 李翠 LIU Jing;LIU Hongmin;LI Cui(Hengshui Maternal and Child Health Hospital,Hengshui,Hebei,China 053000)

机构地区:[1]河北省衡水市妇幼保健院,河北衡水053000

出  处:《中国药业》2024年第13期100-103,共4页China Pharmaceuticals

基  金:河北省中医药管理局中医药类科学研究项目[2023461]。

摘  要:目的探讨四磨汤口服液联合小儿化食口服液治疗小儿功能性便秘的临床疗效。方法选取医院2022年6月至2023年3月收治的小儿功能性便秘患儿120例,按随机数字表法分为观察组和对照组,各60例。两组患儿均予四磨汤口服液治疗,观察组患儿加用小儿化食口服液,均治疗8周。结果观察组患儿的总有效率为93.33%,显著高于对照组的80.00%(P<0.05)。治疗后,两组患儿中医证候积分均显著降低,且观察组患儿均显著低于对照组(P<0.05);两组患儿的排便间隔及排便时间均显著缩短,且观察组患儿显著短于对照组(P<0.05);两组患儿的双歧杆菌、肠球菌、乳酸杆菌、真杆菌菌落数均显著升高,且观察组患儿显著高于对照组(P<0.05)。观察组患儿治疗后7,14,21,28 d的大便性状评分均显著高于对照组(P<0.05)。观察组和对照组的不良反应发生率相当(6.67%比20.00%,P>0.05)。结论四磨汤口服液联合小儿化食口服液治疗小儿功能性便秘的临床疗效良好,可改善中医证候、临床症状、大便性状和肠道微生态,且安全性良好。Objective To investigate the clinical efficacy of Simo Tang Oral Liquid combined with Xiao'er Huashi Oral Liquid in the treatment of functional constipation in children.Methods A total of 120 children with functional constipation admitted to the hospital from June 2022 to March 2023 were selected and divided into the observation group and the control group by the random number table method,with 60 cases in each group.The children in the two groups were treated with Simo Tang Oral Liquid,on this basis,the children in the observation group were treated with Xiao'er Huashi Oral Liquid.Both groups were treated for 8 weeks.Results The total effective rate in the observation group was 93.33%,which was significantly higher than 80.00%in the control group(P<0.05).After treatment,the traditional Chinese medicine(TCM)syndrome score in the two groups significantly decreased,and that in the observation group was significantly lower than that in the control group(P<0.05).The defecation interval and defecation time in the two groups significantly shortened,and those in the observation group were significantly shorter than those in the control group(P<0.05).The colony numbers of Bifidobacterium,Enterococcus,Lactobacillus,and Bacillus in the two groups significantly increased,and those in the observation group were significantly shorter than those in the control group(P<0.05).The stool characteristics scores in the observation group were significantly higher than those in the control group 7,14,21,and 28 days after treatment(P<0.05).The incidence of adverse reactions between the observation group and the control group was comparable(6.67%vs.20.00%,P>0.05).Conclusion Simo Tang Oral Liquid combined with Xiao'er Huashi Oral Liquid has good clinical efficacy and safety in the treatment of functional constipation in children,which can improve TCM syndrome and clinical symptoms,stool characteristics,and intestinal microbiota.

关 键 词:四磨汤口服液 小儿化食口服液 功能性便秘 排便间隔 大便性状 中医证候 临床疗效 

分 类 号:R932[医药卫生—生药学] R285.6[医药卫生—药学]

 

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