氧化应激与不孕症研究进展  

Research Progress on Oxidative Stress and Infertility

作　　者：王小兰 张海东[1] 周惠芳[1,2] WANG Xiaolan;ZHANG Haidong;ZHOU Huifang(Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing,Jiangsu,China,210029;Nanjing University of Chinese Medicine,Nanjing,Jiangsu,China,210023)

机构地区：[1]南京中医药大学附属医院,江苏南京210029 [2]南京中医药大学,江苏南京210023

出　　处：《河南中医》2024年第7期1121-1127,共7页Henan Traditional Chinese Medicine

基　　金：国家自然科学基金项目(81973898);江苏省研究生科研与实践创新计划项目(KYCX22_1944);江苏省社会发展重大项目(BE2021726)。

摘　　要：生理状态下,机体所产生的少量活性氧在女性生殖过程中(例如卵泡的发育成熟、排卵、黄体的活性、胚胎着床等)通过不同的信号传导途径而发挥重要的作用;病理状态下,过多的活性氧则会引发氧化应激反应,导致生物体代谢异常,线粒体功能受损,介导炎症反应,最终引发疾病。黄体功能不全、子宫内膜异位症、原因不明性不孕症等生殖内分泌疾病的发病皆与氧化应激有一定的相关性,且中西医通过抗氧化治疗不孕症,均可获得满意疗效。目前,抗氧化剂的运用虽然能够有效缓解氧化应激状态,但对其剂量、服用时间等仍未有全面认识,有待更进一步临床研究;其次,中药复方成分复杂,对于其作用机制有待深入探讨,为氧化应激在女性不孕症方面的研究及用药安全性提供支持证据;此外,人类的健康状态、生活方式等也是被认为是影响氧化应激的重要因素。因此,在接受抗氧化治疗的同时也应建立规律的生活方式,适当运动锻炼,有利于机体发挥抗氧化作用。In physiological conditions,the small amount of reactive oxygen species produced by the body plays an important role in female reproductive processes(such as the development and maturation of follicles,ovulation,the activity of the corpus luteum,and embryo implantation,etc.) through different signal transduction pathways.In pathological conditions,excessive reactive oxygen species can trigger oxidative stress,leading to metabolic dysfunction,mitochondrial dysfunction,inflammatory responses,and ultimately,the onset of disease.There is a certain correlation between oxidative stress and various reproductive endocrine disorders such as luteal phase defect,endometriosis,and unexplained infertility.Both Western medicine and TCM can achieve satisfactory therapeutic effects by using antioxidant therapy to treat infertility.Currently,although the use of antioxidants can effectively alleviate oxidative stress,there is still no comprehensive understanding of its dosage,administration time,etc.More clinical research is needed.Secondly,the complex components of Chinese medicinal compounds make it necessary to continuously deepen the exploration of their mechanisms of action,which can provide supportive evidence for the study of oxidative stress in female infertility and the safety of drug use.In addition,human health status and lifestyle are also considered to be important factors affecting oxidative stress.Therefore,in addition to receiving antioxidant treatment,it is also advisable to establish a regular lifestyle and engage in appropriate exercise,which will help the body to exert its antioxidant function.

关 键 词：氧化应激 不孕症 抗氧化治疗 黄体功能不全 子宫内膜异位症 原因不明性不孕症 

分 类 号：R271.911.6[医药卫生—中西医结合]