丹参川芎嗪注射液联合替格瑞洛治疗急性心肌梗死的效果及对心肌损伤标志物、血小板因子的影响  

Effect of salviae miltiorrhizae and ligustrazine hydrochloride injection combined with ticagrelor in the treatment of acute myocardial infarction and its influences on myocardial injury markers and platelet factors

作　　者：王岑 WANG Cen(Xi'an Gaoxin Hospital,Xi'an 710075,China)

机构地区：[1]西安高新医院,陕西西安710075

出　　处：《临床医学研究与实践》2024年第19期53-57,共5页Clinical Research and Practice

摘　　要：目的探讨丹参川芎嗪注射液联合替格瑞洛治疗急性心肌梗死的效果及对心肌损伤标志物、血小板因子的影响。方法选择2020年6月至2022年7月收治的80例急性心肌梗死患者为研究对象,按照随机数字表法将其分为对照组与观察组,各40例。对照组采用替格瑞洛治疗,观察组在对照组基础上加用丹参川芎嗪注射液治疗。比较两组的治疗效果。结果观察组的治疗总有效率高于对照组(P<0.05)。治疗后,观察组的肌酸激酶同工酶(CK-MB)、肌钙蛋白I(c TnI)及N末端脑钠肽前体(NT-proBNP)水平均低于对照组(P<0.05)。治疗后,观察组的血小板活化因子(PAF)、α颗粒膜糖蛋白-140(GMP-140)及血小板第4因子(PF4)水平均低于对照组(P<0.05)。治疗后,观察组的室间隔厚度(IVST)、左室心肌质量指数(LVMI)均低于对照组(P<0.05)。结论丹参川芎嗪注射液联合替格瑞洛治疗急性心肌梗死的效果满意,可有效降低心肌损伤标志物水平,抑制血小板因子表达,改善心室重构,值得推广。Objective To investigate the effect of salviae miltiorrhizae and ligustrazine hydrochloride injection combined with ticagrelor in the treatment of acute myocardial infarction and its influences on myocardial injury markers and platelet factors.Methods A total of 80 patients with acute myocardial infarction admitted from June 2020 to July 2022 were selected as the research objects and divided into control group and observation group according to the random number table method,with 40 cases in each group.The control group was treated with ticagrelor,and the observation group was treated with salviae miltiorrhizae and ligustrazine hydrochloride injection on the basis of the control group.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05).After treatment,the levels of creatine kinase-MB(CK-MB),cardiac troponin I(cTnI)and N-terminal pro-brain natriuretic peptide(NT-proBNP)in the observation group were lower than those in the control group(P<0.05).After treatment,the levels of platelet activating factor(PAF),granule membrane protein-140(GMP-140)and platelet factor 4(PF4)in the observation group were lower than those in the control group(P<0.05).After treatment,the interventricular septal thickness(IVST)and left ventricular myocardial mass index(LVMI)in the observation group were lower than those in the control group(P<0.05).Conclusion Salviae miltiorrhizae and ligustrazine hydrochloride injection combined with ticagrelor in the treatment of acute myocardial infarction has satisfactory effect,it can effectively reduce the levels of myocardial injury markers,inhibit the expression of platelet factors,and improve ventricular remodeling,which is worth promoting.

关 键 词：丹参川芎嗪注射液 替格瑞洛 急性心肌梗死 心肌损伤标志物 血小板因子 

分 类 号：R542.22[医药卫生—心血管疾病]