Molecular and cellular mechanisms of neuroprotection by oligopeptides from snake venoms  

作　　者：CARLOS ALBERTO-SILVA BRENDA RUFINO DA SILVA 

机构地区：[1]Natural and Humanities Sciences Center,Experimental Morphophysiology Laboratory,Federal University of ABC(UFABC),São Bernardo do Campo,São Paulo,Brazil

出　　处：《BIOCELL》2024年第6期897-904,共8页生物细胞（英文）

基　　金：This work received funding from the State of São Paulo Research Foundation(FAPESP)and the Coordination for the Improvement of Higher Education Personnel(CAPES)under Finance Code 001.

摘　　要：Venom snake-derived peptides have multiple biochemical,pharmacological,and toxicological profiles,allowing for the discovery of new medicinal products and therapeutic applications.This review specifically examines the fundamental elements of neuroprotection offered by different oligopeptides derived from snake venom.It also includes a brief evaluation of short peptides that are being considered as potential therapeutic agents.Proline-rich peptides and tryptophyllin family peptides isolated from the crude venom of Viperidae family snakes,specifically Bothrops atrox,Bothrops jararaca,and Bothrops moojeni,have been shown to have pro-survival properties,the ability to reduce oxidative stress,and the ability to promote cell viability and mitochondrial functions.Three significant mechanisms are related to the neuroprotection mediated by snake venom oligopeptides:(1)Activation of the L-arginine metabolite pathway,such as polyamines from ornithine metabolism,which reduces N-methyl-D-aspartate(NMDA)-type glutamate receptor activity;(2)Enhancement of cell viability by activating the nerve growth factor-signaling pathway;and(3)Activation of the Muscarinic acetylcholine receptor subtype M1(mAChR-M1).These small peptides show promise as neuroprotective agents against a variety of neurodegenerative disorders.

关 键 词：Neuroprotective peptides Neurodegenerative disease Oxidative stress Reactive oxygen species Biopeptides 

分 类 号：R33[医药卫生—人体生理学]