黄芩苷改善睡眠障碍引起的认知功能障碍机制的研究进展  

Advances in Understanding the Mechanism of Baicalin in AmelioratingCognitive Dysfunction Associated with Sleep Disorders

作　　者：向桂珍 苏晓静 贾建新[1] 杨占君[1] 宋嵬[1] 孙毅红 闫旭升[1] Xiang Guizhen;Su Xiaojing;Jia Jianxin;Yang Zhanjun;Song Wei;Sun Yihong;Yan Xusheng(Inner Mongolia University of Science and Technology Baotou Medical College,Baotou 014040;Department of Human Anatomy,Baotou Medical College,Inner Mongolia University of Science and Technology,Baotou 014040)

机构地区：[1]内蒙古科技大学包头医学院,包头014040 [2]内蒙古科技大学包头医学院医学技术与麻醉学院,包头014040

出　　处：《国际老年医学杂志》2024年第4期482-485,共4页International Journal of Geriatrics

基　　金：国家自然科学基金项目(81860215);内蒙古自治区卫生健康委医疗卫生科技计划项目(202201400)。

摘　　要：黄芩苷(BA)是从黄芩根部分离出来的黄酮类化合物,具有抗炎、抗氧化、抗凋亡及显著的神经保护作用,且安全性高、副作用小。BA可用于防治中枢系统疾病所致的认知功能障碍、学习记忆缺陷等。睡眠障碍(SD)常伴随认知功能障碍,BA可改善上述症状,但机制尚不明确。本文就BA药理作用及其在SD导致的认知功能障碍中的研究进展进行综述,以期为BA的开发和利用以及认知功能障碍的中药治疗提供新的思路。Baicalin(BA),a flavonoid extracted from the roots of Scutellaria baicalensis,has significant neuroprotective,anti-inflammatory,antioxidant,and anti-apoptotic properties,with a notable safety profile and low negative effects.BA has been acknowledged for its capacity to prevent and cure cognitive deficits and learning impairments linked to illnesses of the central nervous system.Simultaneously,sleep disorders(SD),which often occur along with cognitive dysfunctions,have shown improvement with BA therapy,but the exact reasons behind this improvement are not yet completely understood.This study presents a comprehensive overview of the existing pharmacological knowledge on BA and examines its recent progress in treating cognitive deficits.The goal is to provide fresh insights on how to effectively use BA and traditional Chinese medicine for addressing cognitive dysfunctions.

关 键 词：黄芩苷 睡眠障碍 认知功能障碍 

分 类 号：R285[医药卫生—中药学]