基于中医阴阳理论探讨肿瘤相关巨噬细胞极化在肺癌中的作用  

Discussion on the Effects of Tumor-associated Macrophages Polarization on Lung Cancer Based on the TCM Yin-yang Theory

作　　者：王玉[1] 张露 黄思敏 于东东 汤磊磊 陆婷婷[1,3,4] WANG Yu;ZHANG Lu;HUANG Simin;YU Dongdong;TANG Leilei;LU Tingting(School of Integrated Chinese and Western Medicine,Anhui University of Chinese Medicine,Hefei 230012,China;First Affiliated Hospital of Anhui University of Chinese Medicine,Hefei 230031,China;Anhui Provincial Key Laboratory for the Application and Transformation of Traditional Chinese Medicine in the Prevention and Treatment of Major Pulmonary Diseases,Hefei 230031,China;Institute of Traditional Chinese Medicine Respiratory Disease Prevention and Treatment,Anhui Academy of Chinese Medicine,Hefei 230031,China)

机构地区：[1]安徽中医药大学中西医结合学院,安徽合肥230012 [2]安徽中医药大学第一附属医院,安徽合肥230031 [3]中医药防治肺系重大疾病应用转化安徽省重点实验室,安徽合肥230031 [4]安徽省中医药科学院中医呼吸病防治研究所,安徽合肥230031

出　　处：《中国中医药信息杂志》2024年第7期14-19,共6页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：国家自然科学基金青年基金(82104454);安徽省自然科学基金青年基金(2108085QH376);安徽省高校优秀拔尖人才培育资助项目(gxyq2020018);安徽中医药大学高层次人才支持计划项目(2021rcyb009);安徽中医药大学大学生创新创业训练计划(202110369041);安徽高校研究生科学研究项目(YJS20210482);安徽省新时代育人质量工程项目(研究生教育)(2022xscx105)。

摘　　要：肺癌是我国恶性肿瘤中发病率和病死率均居首位的癌症类型,肿瘤相关巨噬细胞(TAMs)与肺癌发生发展、侵袭转移等过程及治疗耐受问题密切相关。本文通过梳理肺癌中医病因病机及TAMs在肺癌中的关键作用,发现TAMs的局部阴阳失衡和肿瘤微环境、机体的整体阴阳失衡是肺癌形成和进展的重要原因。在肺癌病程及转归系列过程中,M1、M2型TAMs各自发挥不同作用,且具有不同阴阳属性,二者保持不断发展变化的互根互用、对立制约、消长平衡状态。基于中医阴阳理论,根据肺癌进展程度和阴阳失衡状态,合理选方用药调整TAMs表型,促进整体阴阳稳衡,可为肺癌临床防治提供参考。Lung cancer is the cancer type with the highest incidence rate and mortality among malignant tumors in China.Tumor associated macrophages(TAMs)are closely related to the occurrence,development,invasion and metastasis,and treatment tolerance of lung cancer.This article explored the etiology and pathogenesis of lung cancer in TCM,as well as the key role of TAMs in lung cancer.It was found that the local imbalance of yin and yang in TAMs,as well as the overall imbalance of yin and yang in the tumor microenvironment and whole body,were important reasons for the formation and progression of lung cancer.In the progression and sequelae of lung cancer,M1 and M2 type TAMs each plays different roles and has different yin and yang properties.Both of them maintain a constantly developing and changing state of mutual use,opposing constraints,and balance of growth and decline.Based on the yin-yang theory in TCM,according to the progression of lung cancer and the imbalance of yin and yang,rational selection and medication can adjust the phenotype of TAMs,promote the overall balance of yin and yang,and provide reference for the clinical prevention and treatment of lung cancer.

关 键 词：肿瘤相关巨噬细胞 表型 阴阳平衡 肺癌 

分 类 号：R273.42[医药卫生—中西医结合]