中医药调控细胞自噬研究文献可视化分析  

Visualization Analysis of Research on the TCM Regulation of Cellular Autophagy

作　　者：龙丹 毛晨晗 刘雅璇 邹君君[3] 徐寅[1] 朱莹 LONG Dan;MAO Chenhan;LIU Yaxuan;ZOU Junjun;XU Yin;ZHU Ying(The First Hospital of Hunan University of Chinese Medicine,Changsha 410021,China;Affiliated Hospital of Integrated Traditional Chinese and Western Medicine,Nanjing University of Chinese Medicine,Nanjing 210028,China;The Second Affiliated Hospital of Hunan University of Chinese Medicine,Changsha 410005,China)

机构地区：[1]湖南中医药大学第一附属医院,湖南长沙410021 [2]南京中医药大学附属中西医结合医院,江苏南京210028 [3]湖南中医药大学第二附属医院,湖南长沙410005

出　　处：《中国中医药信息杂志》2024年第7期50-56,共7页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：国家自然科学基金(81874466);全国名老中医药专家传承工作室建设项目(2022年);湖南省自然科学基金青年基金(S2021JJQNJJ2244);湖南中医药大学研究生创新课题(2022CX132)。

摘　　要：目的探索中医药调控细胞自噬研究现状、热点及趋势,为相关研究提供参考。方法计算机检索中国知识资源总库(CNKI)、中国学术期刊数据库(万方数据)、中文科技期刊数据库(VIP)和中国生物医学文献数据库(CBM)建库至2022年12月31日收录的中医药调控细胞自噬相关研究文献。采用CiteSpace5.7.R5软件绘制作者及机构合作视图,对关键词进行突现分析并绘制时间线图。采用VOSviewer1.6.18软件绘制关键词共现网络。结果纳入文献2001篇,发文量总体呈上升趋势。作者合作团队以贾连群、杨关林、宋囡等为主。发文较多的研究机构包括湖南中医药大学、辽宁中医药大学、广州中医药大学等。文献关键词形成了9个有意义的聚类,显示该领域研究热点主要集中于凋亡、线粒体自噬、实验研究、信号通路、中药单体等;受关注的中医药干预手段有电针、灸法、白藜芦醇、姜黄素等,主要涉及PI3K/Akt、AMPK/mTOR等信号通路的研究。结论中医药领域细胞自噬相关研究近年热度较高。实验研究、分子机制、相关疾病、中医药干预为该领域研究热点。研究趋势以中药单体、中医理论研究等方向为主,主要围绕凋亡、氧化应激等途径开展研究。Objective To explore the current status,hotspots and trends of research on the TCM regulation of cellular autophagy;To provide reference for related research.Methods The literature related to the TCM regulation of cellular autophagy was retrieved from CNKI,Wanfang Data,VIP and CBM from the establishment of the databases to December 31,2022.Authors and institutional collaboration networks were drawn using CiteSpace 5.7.R5.keywords emergence analysis and timeline view were drawn.VOSviewer 1.6.18 software was used to draw keyword co-occurrence mapping.Results A total of 2001 articles were included,with a general upward trend in the number of publications.The cooperation teams were mainly represented by Jia Lianqun,Yang Guanlin,Song Nan and others.Research institutions with more publications included Hunan University of Chinese Medicine,Liaoning University of Chinese Medicine,and Guangzhou University of Chinese Medicine.The keywords of the literature formed 9 meaningful clusters,showing that the research hotspots in this field mainly focused on apoptosis,mitochondrial autophagy,experimental studies,signaling pathways,and herbal monomers,etc.TCM interventions that attracted much attention included electroacupuncture,moxibustion,resveratrol,curcumin,etc,mainly involving PI3K/Akt,AMPK/mTOR and other signaling pathways.Conclusion The research on cellular autophagy in the field of TCM has been highly popular in recent years.Experimental studies,molecular mechanisms,related diseases,and TCM intervention are the research hotspots in this field.The research trend is dominated by TCM monomer,TCM theory research and other directions,mainly focusing on apoptosis,oxidative stress and other pathways to carry out extensive research.

关 键 词：中医药 自噬 知识图谱 文献计量学 CITESPACE VOSviewer 

分 类 号：R2-03[医药卫生—中医学]