平胃散加味联合毫火针对直肠癌患者化学治疗致胃肠道反应的疗效  

Effect of modified Pingwei powder combined with filiform fire-needle on chemotherapy induced gastrointestinal reactions in rectal cancer patients

作　　者：马虹宇[1] 陈元武[2] 张明明[3] 岳向勇[4] 檀碧波[5] Ma Hongyu;Chen Yuanwu;Zhang Mingming;Yue Xiangyong;Tan Bibo(Department of Traditional Chinese Medicine,Hebei Provincial People's Hospital,Shijiazhuang 050057,China;Department of Rehabilitation,Hebei Provincial People's Hospital,Shijiazhuang 050057,China;The Center for Clinical Medical Research,Hebei Provincial People's Hospital,Shijiazhuang 050057,China;Department of Oncology,Hebei Provincial People's Hospital,Shijiazhuang 050057,China;Third Department of Surgery,The Fourth Hospital of Hebei Medical University,Shijiazhuang 050011,China)

机构地区：[1]河北省人民医院中医科,石家庄050057 [2]河北省人民医院康复科,石家庄050057 [3]河北省人民医院临床医学研究中心,石家庄050057 [4]河北省人民医院肿瘤二科,石家庄050057 [5]河北医科大学第四医院外三科,石家庄050011

出　　处：《中华消化病与影像杂志（电子版）》2024年第4期297-300,共4页Chinese Journal of Digestion and Medical Imageology(Electronic Edition)

基　　金：河北省医学科学研究项目(20190756)。

摘　　要：目的探讨平胃散加味联合毫火针对直肠癌患者化学治疗(简称化疗)导致胃肠道反应的疗效和影响。方法选取2020年10月至2023年2月于河北省人民医院和河北医科大学第四医院就治的直肠癌患者108例进行前瞻性分析,根据随机数字1∶1列表法分为对照组(n=54)和观察组(n=54),对照组予以mFOLFOX6化疗方案,观察组在化疗方案基础上予以平胃散加味联合毫火针治疗,对比两组治疗化疗胃肠道反应的疗效、中医症候积分、胃肠激素水平、健康状态及生命质量。结果治疗后,观察组临床治疗有效率显著高于对照组(P<0.05),恶心呕吐等中医症候评分显著低于对照组(P<0.05),血清胃泌素、胃动素水平显著低于对照组,卡氏功能状态评分、生命质量评分较对照组高(P<0.05)。结论平胃散加味联合毫火针对治疗直肠癌患者化疗致胃肠道反应具有较好的疗效,可有效改善胃肠道症状,调节胃肠激素水平,提升健康状况和生命质量。Objective To explore the effect of modified Pingwei powder combined with filiform fire-needle on chemotherapy induced gastrointestinal reactions in patients with rectal cancer.Methods A prospective analysis was conducted on 108 patients with rectal cancer who were treated in Hebei Provincial People's Hospital and the Fourth Hospital of Hebei Medical University from October 2020 to February 2023.They were randomly divided into a control group(n=54)and an observation group(n=54)using a 1∶1 random number listing method.The control group received mFOLFOX6 chemotherapy regimen,while the observation group received Pingwei powder combined with filiform fire-needle therapy on the basis of the chemotherapy regimen.The therapeutic effects of chemotherapy gastrointestinal reactions,traditional Chinese medicine syndrome scores,gastrointestinal hormone levels,Health status and quality of life were compared between the two groups.Results After treatment,the clinical efficacy rate of the observation group was significantly higher than that of the control group(P<0.05),and the scores of traditional Chinese medicine symptoms such as nausea and vomiting were significantly lower than those of the control group(P<0.05).The levels of gastrointestinal hormones such as serum gastrin and motilin were significantly lower than those of the control group,and the scores of Karnofsky performance status(KPS)and quality of life score were higher than those of the control group(P<0.05).Conclusion The combination of Pingwei powder and filiform fire-needle has a good therapeutic effect on chemotherapy induced gastrointestinal reactions in rectal cancer patients,and can effectively improve gastrointestinal symptoms,regulate gastrointestinal hormone levels,and enhance health status and quality of life.

关 键 词：直肠癌 平胃散加味 毫火针 化学治疗 胃肠道反应 

分 类 号：R273[医药卫生—中西医结合]