利巴韦林联合复方嗜酸乳杆菌治疗轮状病毒肠炎患儿的临床研究  

Clinical study of ribavirin combined with compound lactobacillus acidophilus in the treatment of children with rotavirus enteritis

作　　者：李秀玲 连少锋 荣刘涛 李登峰 饶蕴玉 Li Xiuling;Lian Shaofeng;Rong LiuTao;Li Dengfeng;Rao Yunyu(Department of Paediatrics,Jieshou City People's Hospital of Anhui Province,Jieshou 236500,China;Department Of Clinical Laboratory,Jieshou City People's Hospital of Anhui Province,Jieshou 236500,China)

机构地区：[1]界首市人民医院儿科,安徽省236500 [2]界首市人民医院检验科,安徽省236500

出　　处：《中华消化病与影像杂志（电子版）》2024年第4期369-372,共4页Chinese Journal of Digestion and Medical Imageology(Electronic Edition)

摘　　要：目的探讨利巴韦林联合复方嗜酸乳杆菌治疗轮状病毒肠炎(RVE)患儿疗效及对血清晚期糖基化终末产物(AGEs)、炎症因子及肠道微生物的影响。方法选取2019年3月至2023年11月界首市人民医院收治RVE患儿100例,采用随机数字表法分为对照组(复方嗜酸乳杆菌)50例,观察组(利巴韦林+复方嗜酸乳杆菌)50例。对比两组临床疗效、血清AGEs和炎性因子水平、肠道菌群水平、肠黏膜屏障指标和胃肠激素,以及轮状病毒转阴情况和用药安全性。结果观察组临床疗效高于对照组(94.54%比81.81%,P<0.05);观察组血清AGEs和炎症因子水平低于对照组(P均<0.05);观察组大肠埃希菌和肠球菌数量低于对照组,乳酸杆菌和双歧杆菌数量高于对照组(P均<0.05);观察组肠黏膜屏障指标和胃肠激素水平低于对照组(P均<0.05);观察组轮状病毒转阴率高于对照组(92.00%比78.00%,P<0.05);观察组与对照组不良反应发生率无差异(8.00%比12.00%,P>0.05)。结论利巴韦林联合复方嗜酸乳杆菌治疗REV患儿能够明显缓解症状、调节肠道菌群、血清AGEs和炎症因子水平,安全性较好。Objective To explore the therapeutic effect of ribavirin combined with compound lactobacillus acidophilus on children with rotavirus enteritis(RVE)and its effects on serum advanced glycation end products(AGEs),inflammatory factors,and intestinal microbiota.Methods A total of 100 children with RVE in Jieshou City People's Hospital from March 2019 to November 2023 were selected.They were divided into a control group(compound lactobacillus acidophilus,n=50)and an observation group(ribavirin+compound lactobacillus acidophilus,n=50)using a random number table method.The clinical efficacy,serum AGEs and inflammatory factor levels,gut microbiota levels,intestinal mucosal barrier indicators and gastrointestinal hormones,as well as the conversion of rotavirus to negative and medication safety between the two groups were compared.Results The clinical efficacy of the observation group was higher than that of the control group(94.54%vs.81.81%,P<0.05).The levels of AGEs and inflammatory factors in the observation group were lower than those in the control group(both P<0.05).The numbers of Escherichia coli and Enterococcus in the observation group was lower than those in the control group,while the numbers of Lactobacillus and Bifidobacterium were higher than those in the control group(both P<0.05).The intestinal mucosal barrier indicators and gastrointestinal hormone levels in the observation group were lower than those in the control group(both P<0.05).The negative conversion rate of rotavirus in the observation group was higher than that in the control group(92.00%vs.78.00%,P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(8.00%vs.12.00%,P>0.05).Conclusion The combination of ribavirin and compound lactobacillus acidophilus can significantly alleviate symptoms,regulate the levels of intestinal flora,serum AGEs and inflammatory factor levels,with good safety.

关 键 词：轮状病毒肠炎 利巴韦林 复方嗜酸乳杆菌 晚期糖基化终末产物 炎症因子 肠道微生物 

分 类 号：R725.7[医药卫生—儿科]