血清中IL-6、IL-8、IL-10、TNF-α水平在节段型与非节段型白癜风患者中意义  

Significance of serum IL-6,IL-8,IL-10,TNF-αconcentrations in segmental vitiligo and non-segmental vitiligo

作　　者：闪莹 常晓彤[2] 左亚刚 SHAN Ying;CHANG Xiaotong;ZUO Yagang(Department of Dermatology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,State key laboratory of complex severe and rare diseases,National Clinical Research Center for Dermatologic and Immunologic Diseases,Beijing 100730,China;Hebei North University,Zhangjiakou 075000,China)

机构地区：[1]中国医学科学院,北京协和医学院,北京协和医院皮肤科,疑难重症及罕见病国家重点实验室,国家皮肤与免疫疾病临床医学研究中心,北京100730 [2]河北北方学院,张家口075000

出　　处：《中华临床免疫和变态反应杂志》2024年第3期221-226,共6页Chinese Journal of Allergy & Clinical Immunology

摘　　要：目的白癜风是一种以色素脱失为特征的免疫相关性皮肤病,细胞因子在白癜风发病中扮演重要角色。白癜风分为节段型(SV)、非节段型(NSV)、未定类型和混合型。本研究旨在探讨血清中TNF-α、IL-6、IL-8和IL-10在节段型与非节段型白癜风发病中的意义。方法对2018年1月至2019年12月于北京协和医院皮肤科就诊的161例白癜风患者进行回顾性分析,包括SV(29例)、NSV(131例)、未定类型(1例)和混合型(0例),比较SV和NSV组患者进展期和稳定期血清中TNF-α、IL-6、IL-8和IL-10水平。结果NSV组血清IL-8水平明显高于SV组,存在显著性差异(P=0.022),且NSV组进展期血清中IL-8水平明显高于SV组进展期(P=0.026)。结论血清IL-8在非节段型白癜风发病中可能具有重要作用。Objective Vitiligo is one kind of immune-related cutaneous diseases,characterized by depigmentation.Cytokines play crucial roles in pathogenesis of this disease.Vitiligo is classified into segmental vitiligo(SV),non-segmental vitiligo(NSV),undetermined vitiligo and mixed vitiligo subtypes.The aim of this study was to investigate the significance of serum levels of tumor necrosis factor-α(TNF-α),interleukin(IL)-6,IL-8,and IL-10 in pathogenesis of SV and NSV.Methods A total of 161 vitiligo patients(29 with SV,131 with NSV,1 with undetermined vitiligo and none of mixed vitiligo subtypes)were collected and analyzed retrospectively,who were diagnosed in Department of Dermatology,Peking Union Medical College Hospital since January 2018 to December 2019.The serum levels of TNF-α,IL-6,IL-8 and IL-10 in SV and NSV groups were compared in progressive and stationary phases.Result The IL-8 level of patients with NSV was significantly higher than that of SV patients(P=0.022)and serum IL-8 level was significantly higher in NSV group compared with that in of SV group in progressive stage(P=0.026).Conclusion IL-8 might play an important role in pathogenesis of NSV.

关 键 词：白癜风 节段型 非节段型 肿瘤坏死因子α 白介素6 白介素8 白介素10 

分 类 号：R758.41[医药卫生—皮肤病学与性病学]