那屈肝素钙联合泼尼松治疗小儿肾病综合征的临床效果  

Clinical Effect of Nadroparin Calcium Combined with Prednisone in the Treatment of Nephrotic Syndrome in Children

作　　者：陈钊 Chen Zhao(Department of Pediatrics,Guizhou Provincial People's Hospital,Guiyang 550001,Guizhou Province,China)

机构地区：[1]贵州省人民医院儿科,贵州贵阳550001

出　　处：《中外医药研究》2024年第15期63-65,共3页JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH

摘　　要：目的:探讨那屈肝素钙联合泼尼松治疗小儿肾病综合征的临床效果。方法:选取2022年7月—2024年2月于贵州省人民医院接受治疗的肾病综合征患儿106例作为研究对象,采用随机数表法分为对照组和观察组,各53例。在对症治疗基础上,对照组采用泼尼松治疗,观察组在对照组基础上采用那屈肝素钙治疗。比较两组临床疗效、肾功能、凝血功能、不良反应发生率。结果:观察组总有效率高于对照组,差异有统计学意义(P=0.022)。治疗前,两组24 h尿蛋白定量、血尿素氮(BUN)、血肌酐(Scr)水平比较,差异无统计学意义(P>0.05);治疗后,两组24 h尿蛋白定量、BUN、Scr水平低于治疗前,观察组低于对照组,差异有统计学意义(P<0.05)。治疗前,两组凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)水平比较,差异无统计学意义(P>0.05);治疗后,两组PT、APTT水平高于治疗前,FIB水平低于治疗前,观察组PT、APTT水平高于对照组,FIB水平低于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:那屈肝素钙联合泼尼松治疗小儿肾病综合征的临床效果较好,可改善凝血功能、肾功能,且安全性较高。Objective:To investigate the clinical effect of nadroparin calcium combined with prednisone in the treatment of nephrotic syndrome in children.Methods:A total of one hundred and six children with nephrotic syndrome who received treatment in Guizhou Provincial People's Hospital from July 2022 to February 2024 were selected as the study objects and divided into control group and observation group by random number table method,with fifty-three cases in each group.On the basis of symptomatic treatment,the control group was treated with prednisone,and the observation group was treated with nadroparin calcium on the basis of control group.The clinical efficacy,renal function,coagulation function and incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was higher than that of the control group,the difference was statistically significant(P=0.022).Before treatment,there was no significant difference in 24 h urinary protein,blood urea nitrogen(BUN)and serum creatinine(Scr)levels between the two groups(P>0.05);after treatment,24 h urinary protein quantity,BUN and Scr levels in both groups were lower than before treatment,and observation group was lower than control group,the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in prothrombin time(PT),activated partial thromboplastin time(APTT)and fibrinogen(FIB)levels between the two groups(P>0.05);after treatment,PT and APTT levels were higher than before treatment,FIB levels were lower than before treatment,PT and APTT levels in observation group were higher than control group,FIB levels were lower than control group,the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Nadroparin calcium combined with prednisone in the treatment of children with nephrotic syndrome has good clinical effect,can improve coagulation function,renal function,a

关 键 词：小儿肾病综合征 那屈肝素钙 泼尼松 肾功能 

分 类 号：R726.9[医药卫生—儿科]