一种具备AIE性质的新型近红外荧光化合物的合成和研究  

Synthesis and Study of A Novel Near-Infrared Fluorescent Compound with AIE Properties

作　　者：莫振卓 陈威名 MO Zhenzhuo;CHEN Weiming(Key Laboratory for the Synthesis and Application of Organic Functional Molecules,College of Chemistry and Chemical Engineering,Hubei University,Wuhan,Hubei 430062,China)

机构地区：[1]湖北大学化学化工学院有机功能分子合成与应用重点实验室,湖北武汉430062

出　　处：《浙江化工》2024年第6期14-20,共7页Zhejiang Chemical Industry

基　　金：国家自然科学基金(22007029);武汉-曙光计划知识创新项目(2023020201020415)。

摘　　要：本文设计并合成了一种具有聚集诱导发光(AIE)性质的近红外荧光化合物QS-P,并对其进行1H NMR和质谱结构表征,光物理化学性质研究(包括紫外吸收、荧光发射、量子产率计算、酸度系数pKa计算、油水分配系数Log P计算)和毒性研究。结果显示,QS-P发射达到了近红外区域(≥650 nm),有很大的斯托克斯位移(>200 nm),具备一定的水溶性、pH稳定性、AIE性质,对细胞毒性小。表明QS-P具备应用于生物活体的潜力,可为生物活体探针提供一定的设计思路。A near-infrared fluorescent compound QS-P with aggregation-induced luminescence(AIE)properties was designed and synthesized in this paper.Its structure was characterized by 1H NMR and mass spectrometry,as well as photophysicochemical properties(including ultraviolet absorption,fluorescence emission,quantum yield calculation,acidity coefficient pKa calculation,oil-water partition coefficient Log P calculation) and toxicity study.The results showed that QS-P emission reached the near-infrared region(≥650 nm),had a large Stoke shift(>200 nm),possessed certain water solubility,pH stability,AIE properties,and low toxicity to cells.It shows that QS-P has the potential to be applied to biological in vivo,which provides certain design ideas for biological in vivo probes.

关 键 词：近红外荧光 聚集诱导发光(AIE) 大斯托克斯位移 低毒性 

分 类 号：R313[医药卫生—基础医学] O657.33[理学—分析化学]