器官移植受者侵袭性真菌病的诊疗策略新进展  

New advances in diagnostic and therapeutic strategies for invasive fungal disease in organ transplant recipients

作　　者：巨春蓉[1] 门同义 薛武军[3] Ju Chunrong;Men Tongyi;Xue Wujun(Department of Organ Transplantation(Respiratory and Critical Care),The First Affiliated Hospital of Guangzhou Medical University,Guangzhou Institute of Respiratory Health,National Center for Respiratory Medicine,The State Key Laboratory of Respiratory Disease,Guangzhou310003,China;The Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010030,China;The First Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710061,China)

机构地区：[1]广州医科大学附属第一医院器官移植科(呼吸与危重症科)广州呼吸健康研究院国家呼吸医学中心国家呼吸系统疾病临床医学研究中心呼吸疾病国家重点实验室,广州310003 [2]内蒙古医科大学附属医院,呼和浩特010030 [3]西安交通大学第一附属医院,西安710061

出　　处：《中华器官移植杂志》2024年第4期233-242,共10页Chinese Journal of Organ Transplantation

基　　金：呼吸疾病国家重点实验室/广州呼吸健康研究院/国家呼吸中心临床自主探索项目(SKLRHQN20205);广东省钟南山医学基金会(ZNSA-2020013);广东省自然科学基金(2022A1515012216);广州市临床特色技术项目(2023C-TS10);广州医科大学科研能力提升计划重大临床研究项目(GMUCR2024-01007)。

摘　　要：长期服用免疫抑制剂导致的免疫功能低下状态、反复住院及广谱抗生素的使用、移植相关糖尿病的存在、遗体捐献的增加等因素导致实体器官移植(solid organ transplantation,SOT)受者侵袭性真菌病(invasive fungal disease,IFD)的发生风险日益增加,且近年来SOT受者IFD的流行病学也在不断改变。了解SOT受者IFD的流行病学现状、熟悉IFD的新型诊断技术、掌握新型抗真菌药物特性,有助于进一步改善受者预后。本文针对SOT受者IFD的发病率、致病菌构成、新型诊断技术及近年上市的全新抗真菌药物等方面进行简要阐述,以期为临床提供参考。Long-term use of immunosuppressants result in an immunocompromised state,repeated hospitalizations and dosing of broad-spectrum antibiotics.Presence of transplant-associated diabetes and cadaveric donations are contributing factors to a higher risk of invasive fungal disease(IFD)among solid organ transplantation(SOT)recipients.Furthermore,the epidemiology of IFD in SOT recipients has continuously evolved in recent years.Understanding the current epidemiological status of IFD in SOT recipients,becoming familiar with new diagnostic technologies for IFD and mastering the characteristics of novel antifungal medications may further improve the prognosis for recipients.This review summarized the incidence,pathogen composition,new diagnostic technologies and recently marketed novel antifungal medications for IFD in SOT recipients,aiming to offer references for clinical practices.

关 键 词：器官移植 侵袭性真菌病 抗真菌药 免疫抑制剂 

分 类 号：R699.2[医药卫生—泌尿科学] R519[医药卫生—外科学]