幽门螺杆菌感染对新冠病毒感染的临床表现和转归的影响  

The effect of Helicobacter pylori infectionon clinical course of SARS-CoV-2 infections

作　　者：钟雪晴 王可洋 徐阳 孙逸洁 李国熊[1] ZHONG Xueqing;WANG Keyang;XU Yang;SUN Yijie;LI Guoxiong(Department of Gastroenterology,Affiliated Hospital of Hangzhou Normal University,Hangzhou 300015,China)

机构地区：[1]杭州师范大学附属医院消化内科,浙江杭州300015

出　　处：《健康研究》2024年第3期324-327,共4页Health Research

基　　金：浙江省自然科学基金青年项目(LQ19H030002);杭州市生物医药和健康产业发展扶持科技专项(2022WJC020)。

摘　　要：目的 评估幽门螺杆菌(Helicobacter pylori, Hp)对新冠病毒感染的临床表现和转归的影响。方法 以在医院通过C14呼气试验或快速尿素酶试验检测Hp感染的患者为调查对象,了解其中既往感染新冠病毒的新冠感染表现、症状明显改善的时间,收集患者Hp感染情况及基本社会人口学资料。结果 共调查502例既往新冠感染者,其中189例Hp阳性,313例Hp阴性。Hp阳性者的腹痛发生率(12.2%)、腹胀发生率(10.1%)、腹泻发生率(34.9%),均明显高于Hp阴性者(5.1%、3.5%、24.3%),差异均有统计学意义(P<0.05)。28.8%的Hp阴性者新冠核酸/抗原在一周内转阴,6.3%的Hp阳性者新冠核酸/抗原在一周内转阴,2者差异有统计学意义(P<0.05)。Hp阳性和阴性者感染新冠病毒后3天内症状明显改善的比例,差异无统计学意义(χ^(2)=1.795,P=0.180)。结论 与Hp阴性者相比,Hp阳性者感染新冠病毒后腹痛、腹泻、腹胀的发生率更高;Hp的存在显著影响新冠抗原或核酸转阴时间,但不影响症状缓解的时间。Objective To evaluate the effect of Helicobacter pylori(Hp)on the clinical manifestations and outcomes of SARS-CoV-2 infection.Methods Patients undergoing C14 breath test or rapid urease test for Hp infection in the hospital were selected for investigation.The study aims to understand the clinical presentation of COVID-19 in patients with prior Hp infection,the time frame for significant improvement in symptoms of COVID-19,and to collect data on Hp infection status and basic socio-demographic information of the patients.The survey included the clinical manifestations of SARS-CoV-2,the time to significant symptom improvement among those with a history of SARS-CoV-2 infection,Hp infection status and basic sociodemographic information.Results A total of 502 patients with a history of SARS-CoV-2 infection were surveyed,including 189 Hp-positive and 313 Hp-negative cases.The incidence of abdominal pain(12.2%),abdominal distension(10.1%),and diarrhea(34.9%)in Hp-positive patients were significantly higher than those in Hp-negative patients(5.1%,3.5%,24.3%,respectively),with all differences being statistically significant(P<0.05).Among Hp-negative patients,28.8%had negative conversion of SARS-CoV-2 nucleic acid/antigen within one week,while among Hp-positive patients,only 6.3%had negative conversion within the same period,showing a statistically significant difference(P<0.05);There was no statistically significant differences in the proportion of patients with significant symptom improvement within three days after contracting SARS-CoV-2 between Hp-positive(25.4%)and-negative patients(31.0%)(=1.795,P=0.180).Conclusions Compared to Hp-negative patients,Hp-positive patients had higher rates of abdominal pain,diarrhea,and bloating after contracting SARS-CoV-2.The presence of Hp significantly influenced the time for SARS-CoV-2 antigen or nucleic acid conversion to negative,but did not affect the time for symptom relief.

关 键 词：新冠病毒 幽门螺杆菌 消化系统症状 

分 类 号：R333[医药卫生—人体生理学]