表面等离子体共振的二维相移探测  

Two-dimensional phase shift detection of surface plasmon resonance

作　　者：蒋兹钰 沈艳婷 吴家伟 朱奇峰 郭广生 陈卓 JIANG Ziyu;SHEN Yanting;WU Jiawei;ZHU Qifeng;GUO Guangsheng;CHEN Zhuo(School of Sciences,Zhejiang University of Science and Technology,Hangzhou,Zhejiang 310023,China)

机构地区：[1]浙江科技大学理学院,浙江杭州310023

出　　处：《光电子．激光》2024年第7期731-736,共6页Journal of Optoelectronics·Laser

基　　金：国家自然科学基金(11904318);浙江省自然科学基金(LGC19A040001)。

摘　　要：表面等离子体共振(surface plasmon resonance,SPR)在生物传感中有极大的应用价值,基于棱镜结构的共振角的相位传感比反射率传感具有更高的灵敏度。多通道实时相移探测是SPR生物传感的研究热点和难点。本文提出了一种基于Kretschmann棱镜结构的衰减全反射(attenuated total reflection,ATR)单光路的SPR相位检测系统。通过液晶可变延迟器(liquid crystal variable retarder,LCVR)调控可激发表面等离子体激元(surface plasmon plaritons,SPPs)的P-偏振光和作为参考光的S-偏振光的相位差,实现单光路干涉。通过可寻址的微镜阵列(micro-mirror array,MMA)实现棱镜二维表面的定点相位探测。该系统能够以接近单个MMA像素的空间分辨率(水平/垂直为7.64μm或对角线为10.8μm)探测相移信息,从而实现单光路、高精度、多通道的二维等离子共振相移探测,为原位生物传感器和突破衍射极限的相位成像提供新的实验思路。Surface plasmon resonance(SPR)has tremendous application value in biosensing.The phase sensing of the resonant angle based on a prism structure exhibits higher sensitivity compared with the reflectivity sensing.Multi-channel real-time phase shift detection is a research highlight in SPR biosensing.An SPR phase detection system based on Kretschmann prism structure attenuated total reflection(ATR)single-path is proposed.The phase difference between P-polarized signal light and S-polarized reference light is controlled by a liquid crystal variable retarder(LCVR)to realize single-path interference.Fixed-point phase detection of two-dimensional surfaces is realized by an addressable micro-mirror array(MMA).The system can detect the phase shift information with a spatial resolution close to a single MMA pixel(7.64μm horizontally/vertically or 10.8μm diagonally).It is capable of realizing single-path,high-precision,multi-channel two-dimensional plasmon resonance phase shift detection,providing new experimental ideas for in-situ biosensors and phase imaging beyond diffraction limits.

关 键 词：表面等离子体 单光路 相移 

分 类 号：O43[机械工程—光学工程]