可降解血管吻合器的结构设计与实验验证  

Structure Design and Experimental Verification of a Degradable Vascular Anastomotic Device

作　　者：徐凯悦 蔡雪 胡钟欣 高钦贤 邢绪坡 宋成利[1] 毛琳 XU Kaiyue;CAI Xue;HU Zhongxin;GAO Qinxian;XING Xupo;SONG Chengi;MAO Lin(Shanghai Institute for Minimally Invasive Therapy,School of Health Science and Engineering,University of Shanghai for Science and Technology,Shanghai 200093,China)

机构地区：[1]上海理工大学健康科学与工程学院,现代微创医疗器械及技术教育部工程研究中心,上海200093

出　　处：《医用生物力学》2024年第3期518-523,共6页Journal of Medical Biomechanics

基　　金：国家自然科学基金项目(51901137)。

摘　　要：目的 设计一种新型可降解血管吻合器,探究施压距离与吻合口生物力学性能之间的关系,以提高血管端端吻合的效率与质量。方法 设计吻合器的三维结构,并采用挤压态高纯镁为材料进行样机加工;通过建立血管端端吻合的有限元模型,研究在不同施压距离(0.4、0.5、0.6、0.7、0.8 mm)下,血管吻合端面应力分布情况及其变化规律;通过离体组织吻合实验,对有限元结果的合理性及该吻合器的可行性与有效性进行验证。结果 当施压距离为0.6 mm时,吻合口力学性能最优,此时撕脱力为(11.79±0.64) N,爆破压为(39.32±2.99) kPa,满足临床上对组织吻合口强度的要求,同时组织的机械损伤较小。结论 本文所设计的新型可降解血管吻合器可以通过调节施压距离对组织进行吻合,能够有效提高组织吻合效率,减小组织机械损伤,从而提高吻合质量。研究结果为可降解血管吻合器的设计提供重要参考。Objective To improve the efficiency and quality of end-to-end anastomosis,a novel degradable vascular anastomotic device was designed,and the relationship between pressure distances and biomechanical properties of the anastomotic stoma was explored.Methods The three-dimensional(3D)structure of the vascular anastomotic device was designed and the prototype was fabricated with extruded high-purity magnesium.The finite element model of the end-to-end vascular anastomosis was established to study the stress distributions of the anastomotic end face under different pressure distances(0.4,0.5,0.6,0.7,and 0.8 mm)and their change rules.In vitro experiments were conducted to verify the rationality of the finite element results as well as the feasibility and effectiveness of the vascular anastomotic device.Results When the pressure distance was 0.6 mm,the anastomotic tensile force,and burst pressure could reach(11.79±0.64)N and(39.32±2.99)kPa,respectively,meeting the clinical requirement for the strength of vascular anastomosis,and with the minimal mechanical damages to tissues.Conclusions The device designed in this study can be used for vascular anastomosis by adjusting the pressure distance,and it can improve operation efficiency,reduce mechanical damage to tissues,and further improve the quality of anastomosis.These results provide an essential reference for the design of degradable vascular anastomotic devices.

关 键 词：可降解高纯镁 血管吻合器 端端吻合 施压距离 

分 类 号：R318.01[医药卫生—生物医学工程]