异维A酸红霉素凝胶联合1565 nm非剥脱点阵激光治疗寻常痤疮疗效观察及对皮肤生理指标的影响  

Clinical Efficacy of Erythromycin Isotretinoate Gel Combined with 1565 nm Nonablative Fractional Laser in the Treatment of Acne Vulgaris and Its Effects on Skin Physiological Indexes

作　　者：周虹 谢其美 ZHOU Hong;XIE Qimei(Department of Dermatology,Xuyi County People's Hospital,Huai'an 211700,Jiangsu,China;Department of Medical Aesthetics,the Fourth Affiliated Hospital of Nanjing Medical University,Nanjing 210031,Jiangsu,China)

机构地区：[1]盱眙县人民医院皮肤科,江苏淮安211700 [2]南京医科大学第四附属医院医疗美容科,江苏南京210031

出　　处：《中国美容医学》2024年第7期27-31,共5页Chinese Journal of Aesthetic Medicine

摘　　要：目的:观察异维A酸红霉素凝胶联合1565 nm非剥脱点阵激光治疗寻常痤疮的临床疗效及皮损、血红素含量情况。方法:选取2021年1月-2022年3月盱眙县人民医院和南京医科大学第四附属医院收治的96例寻常痤疮患者为对象,采用随机数字表法分为两组。对照组48例给予1565 nm非剥脱点阵激光治疗,观察组48例在1565 nm非剥脱点阵激光治疗基础上联合异维A酸红霉素凝胶治疗。统计两组临床疗效和不良反应,检测两组前额、鼻部、脸颊皮肤表面pH值、皮脂分泌率和血红素含量,评估两组面部痤疮综合分级系统(GAGS)评分、痤疮特异性生活质量量表(Acne-QOL)评分的差异。结果:观察组总有效率为91.67%(44/48)高于对照组的75.00%(36/48)(P<0.05)。两组治疗前皮肤指标、血红素含量差异无统计学意义(P>0.05)。治疗后,发现两组前额、鼻部、脸颊皮肤表面pH值、皮脂分泌率、血红素含量均较治疗前降低,且观察组低于对照组(均P<0.05)。两组治疗前GAGS评分、Acne-QOL评分差异无统计学意义(P>0.05)。治疗后,发现两组GAGS评分均较治疗前降低,观察组GAGS评分低于对照组(P<0.05);两组Acne-QOL评分均较治疗前升高,观察组Acne-QOL评分高于对照组(P<0.05)。观察组不良反应发生率为10.42%(5/48)与对照组的16.67%(8/48)比较,无统计学意义(P>0.05)。观察组6个月内复发率为8.00%(2/25)低于对照组的33.33%(6/18),差异有统计学意义(P<0.05)。结论:异维A酸红霉素凝胶联合1565 nm非剥脱点阵激光治疗寻常痤疮可改善皮肤生理指标,减轻皮损程度,提高生活质量。Objective To observe the clinical effect of erythromycin isotretinoate gel combined with 1565 nm non-ablative fractional laser in the treatment of acne vulgaris,skin lesions and heme content.Methods A total of 96 patients with acne vulgaris admitted to Xuyi County People's Hospital and the Fourth Affliated Hospital of Nanjing Medical University from January 2021 to March 2022 were selected and divided into two groups by random number table method.The control group was treated with 1565 nm non-ablative fractional laser for 48 cases,and the observation group was treated with 1565 nm non-ablative fractional laser combined with erythromycin isotretinoate gel for 48 cases.The clinical effcacy and adverse reactions of the two groups were analyzed,the skin surface pH value,sebum secretion rate and heme content of the forehead,nose and cheeks of the two groups were detected.The differences of facial Acne Comprehensive Grading System(GAGS)score and acne-specific Quality of Life scale(Acne QOL)score between the two groups were evaluated.Results The total effective rate of the observation group was 91.67%(44/48)higher than that of the control group 75.00%(36/48),and the difference was statistically significant(P<0.05).There were no significant differences in skin indices and heme content between the two groups before treatment(P>0.05).After treatment,it was found that the skin surface pH values,sebum secretion rate and heme content of forehead,nose and cheek of the two groups were lower than before treatment,and the skin surface pH values,sebum secretion rate and heme content of forehead,nose and cheek of the observation group were lower than those of the control group(allP<0.05).There were no significant differences in GAGS score and Acne QOL score between the two groups before treatment(P>0.05).After treatment,GAGS score in both groups was lower than before treatment,and GAGS score in observation group was lower than control group(P<0.05).The score of Acne QOL in both groups was higher than that before treatment,and t

关 键 词：异维A酸红霉素凝胶 非剥脱点阵激光 寻常痤疮 皮肤生理 生活质量 

分 类 号：R758.733[医药卫生—皮肤病学与性病学]