青蒿素及其衍生物纳米药物递送系统和抗肿瘤机制研究  

Study on the Nano-drug Delivery System and Anti-tumor Mechanism of Artemisinin and Its Derivatives

作　　者：胡晓娴 赵雨 王赟 徐晓 韩超 HU Xiao-xian;ZHAO Yu;WANG Yun;XU Xiao;HAN Chao(School of Traditional Chinese Pharmacy,China Pharmaceutical University,Nanjing 210000,China)

机构地区：[1]中国药科大学中药学院,江苏南京210000

出　　处：《化学试剂》2024年第7期11-19,共9页Chemical Reagents

基　　金：中央高校基本科研业务费专项资金资助项目(2632021ZD24)。

摘　　要：青蒿素是从菊科蒿属植物黄花蒿中分离得到的倍半萜内酯,具有显著的截疟、消炎、抗肿瘤等生物活性。但其具有溶解度低、生物利用度差、结构不稳定等缺点,因此青蒿素衍生物蒿甲醚、青蒿琥酯、双氢青蒿素等应运而生,得以改善以上缺点。目前,青蒿素及其衍生物的抗肿瘤活性受到了广泛关注,并针对其作用机制展开深入研究,科学地解释了其抗癌的特异性和高效性。此外,为了提高青蒿素及其衍生物的生物利用度,还设计了一系列纳米药物递送系统,将其精准地靶向到肿瘤部位,提高其药效。总结和展望了青蒿素及其衍生物的抗肿瘤机制以及新型纳米制剂,以期对青蒿素的研究和新药研发提供帮助。Artemisinin is a sesquiterpene lactone isolated from Artemisia annua L.,family Asteraceae,with remarkable biological activities such as malaria interception,anti-inflammatory and anti-tumor.However,it has the disadvantages such as low solubility,poor bioavailability,and unstable structure.Thus,artemisinin derivatives such as artemether,artesunate,and dihydroartemisinin have been developed to overcome the above shortcomings.At present,the anti-tumor activity of artemisinin and its derivatives has received widespread attention,and in-depth studies have been carried out on their mechanism of action,scientifically explaining their anticancer specificity and efficiency.In addition,to improve the bioavailability of artemisinin and its derivatives,a series of nano-drug delivery systems have been designed to precisely target the tumor sites and enhance their therapeutic efficacy.In this regard,the anti-tumor mechanisms of artemisinin and its derivatives as well as novel nanoformulations were summarized,aiming to provide support for further research and new drug development based on artemisinin.

关 键 词：青蒿素 青蒿素衍生物 恶性肿瘤 抗肿瘤机制 纳米药物递送系统 

分 类 号：R9[医药卫生—药学]