簕欓花椒的化学成分及药理作用研究进展  

Research Progress on Chemical Components and Pharmacological Activities of Zanthoxylum avicennae (Lam.) DC.

作　　者：区楚茵 王丽娜 张笑 肖雪 李莎莎 严诗楷[1,4] 金慧子 OU Chu-yin;WANG Li-na;ZHANG Xiao;XIAO Xue;LI Sha-sha;YAN Shi-kai;JIN Hui-zi(School of Pharmacy,Shanghai Jiao Tong University,Shanghai 200240,China;Institute of Chinese Medicinal Sciences,Guangdong Pharmaceutical University,Guangzhou 510006,China;NMPA Key Laboratory for Rapid Testing Technology of Drugs,Guangdong Institute for Drug Control,Guangzhou 510663,China;The Second Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine,Guangzhou 510006,China)

机构地区：[1]上海交通大学药学院,上海200240 [2]广东药科大学中医药研究院,广东广州510006 [3]国家药品监督管理局药品快速检验技术重点实验室(广东省药品检验所),广东广州510663 [4]广州中医药大学第二附属医院,广东广州510006

出　　处：《化学试剂》2024年第7期59-65,共7页Chemical Reagents

基　　金：国家药品监督管理局快速检验技术重点实验室开放课题项目(KF2022002,KF2022006);广州市科技计划项目珠江科技新星专项项目(201610010113)。

摘　　要：簕欓花椒(Zanthoxylum avicennae)是我国传统中药材,在民间用作草药,有祛风化湿、消肿通络等作用,用于黄疸、咽喉肿痛、疟疾、风湿骨痛、跌打挫伤等症状。据文献报道含有香豆素类、生物碱、木脂素、三萜、黄酮、甾体、芳香族、挥发油等化学成分。目前已发现簕欓花椒具有抗氧化、抑菌、抗肿瘤、镇痛抗炎等多种药理活性,具有一定的药用价值。基于近年来公开发表的文献,对簕欓花椒的化学成分和药理作用进行归纳总结,为其日后的研究及开发利用提供理论依据。Zanthoxylum avicennae(Lam.)DC.is a traditional Chinese herbal medicine in China,which contains coumarins,alkaloids,steroids,triterpenoids,aromatic,volatile oils,and other chemical compositions.It has been found that Z.avicennae possesses a wide range of pharmacological activities,such as antioxidant,antibacterial,anti-tumor,and anti-inflammatory activities,indicating its significant medicinal value.Based on literature published in recent years,this paper summarized the chemical components and pharmacological effects of Z.avicennae,providing a theoretical basis for its future research and utilization.

关 键 词：簕欓花椒 药理作用 化学成分 抗氧化 抑菌 抗肿瘤 镇痛抗炎 免疫调节 

分 类 号：TB34[一般工业技术—材料科学与工程]