纳米材料靶向药物递送系统在骨关节炎治疗中的研究进展  

Research Progress of Nanomaterial Targeted Drug Delivery in Osteoarthritis Treatment

作　　者：张颖煜 赵琳琳 李良骁 刘营营 刘亚军 Zhang Yingyu;Zhao Linlin;Li Liangxiao;Liu Yingying;Liu Yajun(Science and Technology Innovation Center,Shandong First Medical University&Shandong Academy of Medical Sciences,Jinan 250117,China;School of Public Health,Shandong First Medical University&Shandong Academy of Medical Sciences,Jinan 250117,China;Medical Science and Technology Innovation Center,Shandong First Medical University&Shandong Academy of Medical Sciences,Jinan 250117,China;Beijing Jishuitan Hospital Affiliated to Capital Medical University,Beijing Research Institute of Traumatology and Orthopedics,Beijing 100035,China)

机构地区：[1]山东第一医科大学医学科技创新中心,济南250117 [2]山东第一医科大学公共卫生与健康管理学院,济南250117 [3]山东第一医科大学生物医学科学学院,济南250117 [4]北京市创伤骨科研究所,首都医科大学附属北京积水潭医院,北京100035

出　　处：《中国生物医学工程学报》2024年第3期369-376,共8页Chinese Journal of Biomedical Engineering

基　　金：国家自然科学基金(92068119);青年北京学者项目(NO.025);北京市医院管理中心项目(DFL20220401)。

摘　　要：骨关节炎(OA)作为一种高发病率的慢性退行性疾病,其关节内给药治疗颇具挑战。传统的单纯注射方式易导致药物在关节内降解并被快速清除,从而影响疗效。为克服此难题,通过设计组装和外表修饰,现已研发出纳米靶向药物递送系统(DDS),其在病灶部位展现出增加药物浓度、提高治疗疗效并降低毒副作用的优势,已在骨关节炎临床治疗的相关研究中得到广泛应用。通过梳理具有主动靶向功能的纳米药物递送策略,总结了生物靶向配体和仿生生物膜修饰在DDS中的应用成果,并剖析了各种靶向修饰策略的优势与不足,在此基础上,展望了DDS的发展前景,旨在为当前纳米材料的主动靶向修饰策略的发展提供有益参考与建议。Osteoarthritis is a chronic,highly prevalent degenerative disease.Delivering drugs to the joints presents challenges,as free drugs injected into the joints are prone to degradation and rapid clearance through the lymphatic and blood systems.Nano-targeted drug delivery systems,designed with specific assembly and appearance modifications,offer significant advantages.They can increase the drug concentration at the arthritic site,improve efficacy,reduce toxicity,therefore,have been extensively studied for uses in osteoarthritis treatment.This review introduced current nano-drug delivery strategies that featured active targeting in treating osteoarthritis,summarized research work on nano-drug delivery systems enhanced by biotargeting ligands and biomimetic biofilms,highlighting their advantages and limitations.In addition,we discussed the potential future developments of nano-drug delivery systems,aiming to provide references and constructive suggestions for improving the past active targeting and modification strategies of nanomaterials.

关 键 词：骨关节炎 纳米材料 主动靶向 药物递送系统 

分 类 号：R318[医药卫生—生物医学工程]