抗凝血涂层构建方法及发展前景  

The Technologies and Perspectives of Anticoagulant Coating

作　　者：雷少瑾 郑毅[2] 史杰[2,3] 董云生 王淑芳[1] Lei Shaojin;Zheng Yi;Shi Jie;Dong Yunsheng;Wang Shufang(Key Laboratory of Bioactive Materials,Ministry of Education,College of Life Sciences,Nankai University,Tianjin 300071,China;Wenzhou Safety(Emergency)Institute,Tianjin University,Wenzhou 325000,Zhejiang,China;Institute of Disaster and Emergency Medicine,Tianjin University,Tianjin 300072,China)

机构地区：[1]南开大学生命科学学院生物活性材料教育部重点实验室,天津300071 [2]天津大学温州安全(应急)研究院,浙江温州325700 [3]天津大学应急医学研究院,天津300072

出　　处：《中国生物医学工程学报》2024年第3期377-384,共8页Chinese Journal of Biomedical Engineering

基　　金：科技部重大专项(2020YFA0803701);天津市重点项目(20YFZCSY01020,S22ZDF291);国家自然科学基金(31870966)。

摘　　要：随着重大慢性疾病发生以及人口老龄化发展的加速,心血管疾病发病也呈现加速趋势,客观上促进了心血管植入器械的开发,然而为克服制约器械应用的高血栓形成风险,构建其表面抗凝血涂层至关重要,相关研究也是热点层出。综述抗凝血涂层构建方法的国内外研究动态,就物理、化学和生物的构建技术,对传统及最新的抗凝策略进行分析,并就当前面临的重要问题和未来发展的可能路径进行讨论。With acceleration of population aging and urbanization,the number of patients with cardiovascular diseases has gradually increased.Development of cardiovascular implantable devices have attracted increasing attentions in recent years.The high risk of thrombosis is a major factor limiting the application of cardiovascular implanted devices,that is why it is so important to construct anticoagulant coatings on the surface of cardiovascular implanted devices.In this review,we summarized the research progress of anticoagulant coating construction methods in both domestic and foreign researches,analyzed and discussed the conventional and latest anticoagulation strategies from the aspects of physical,chemical and biological methods.Existing problems and prospects of anticoagulation coating construction were also discussed.

关 键 词：生物材料 抗凝血 涂层 构建方法 

分 类 号：R318[医药卫生—生物医学工程]