滤泡辅助T细胞与肾移植体液免疫的研究进展  

Follicular helper T cells and humoral immunity in kidney transplantation

作　　者：孙兆熹(综述) 陈劲松 梁丹丹(审校) SUN Zhaoxi;CHEN Jinsong;LIANG Dandan(National Clinical Research Center for Kidney Diseases,Jinling Hospital,Affiliated Hospital of Medical School,Nanjing Nanjing China)

机构地区：[1]南京大学医学院附属金陵医院(东部战区总医院)国家肾脏疾病临床医学研究中心,南京210016

出　　处：《肾脏病与透析肾移植杂志》2024年第3期285-289,共5页Chinese Journal of Nephrology,Dialysis & Transplantation

基　　金：国家自然科学基金青年项目(82101901)。

摘　　要：抗体介导的排斥反应(ABMR)被认为是造成远期移植物损伤的常见病因,也是移植物失功的重要决定因素。供者特异性抗体(DSA)与ABMR密切相关。滤泡辅助T(Tfh)细胞是促进B细胞增殖分化为浆母细胞和记忆B细胞的关键效应细胞,有助于诱导DSA,参与同种异体移植物的体液免疫反应。本文回顾了Tfh细胞的生物学特性和功能,描述了Tfh细胞在肾移植受者DSA生成和ABMR免疫方面的驱动与调控作用,讨论常规移植免疫疗法对Tfh细胞的影响以及针对性的生物靶向治疗。Antibody-mediated rejection(ABMR)is considered a common cause of long-term graft damage and a significant determinant of transplant failure.Donor-specific antibodies(DSA)are closely associated with ABMR.Follicular helper T(Tfh)cells are the key effector cells in promoting B cell proliferation and differentiation into plasma cells and memory B cells,contributing to the induction of DSAs and participating in the humoral immune response against allografts.This article reviews the biological characteristics and functions of Tfh cells,describes the driving and regulatory role of Tfh cells in DSA production and ABMR immunity of kidney transplant recipients,and discusses the effects of conventional transplantation immunotherapy on Tfh cells and the biological targeted therapy.

关 键 词：滤泡辅助T细胞 移植免疫学 肾移植 抗体介导的排斥反应 

分 类 号：R699.2[医药卫生—泌尿科学]