药物相关Fanconi综合征  

Drug⁃related Fanconi syndrome

作　　者：陈欣 徐鲁斌 叶葳 秦岩 施潇潇 陈丽萌 刘岩 CHEN Xin;XU Lubin;YE Wei;QIN Yan;SHI Xiaoxiao;CHEN Limeng;LIU Yan(Department of Nephrology,State Key Laboratory of Rare Diseases,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences,Beijing 100730,China)

机构地区：[1]中国医学科学院北京协和医院罕见病国家重点实验室肾脏内科,北京100730

出　　处：《肾脏病与透析肾移植杂志》2024年第3期290-294,共5页Chinese Journal of Nephrology,Dialysis & Transplantation

基　　金：科技创新2030——“新一代人工智能”重大项目(2022ZD0116003);国家自然科学基金(82170709,81970607);中国医学科学院医学与健康科技创新工程项目(CIFMS 2021-I2M-1-003);北京市自然科学基金-海淀原始创新联合基金资助(L202035);中央高水平医院临床科研业务费(2022-PUMCH-B-019,2022-PUMCH-D-002)。

摘　　要：25岁男性患者,因“服用中成药近1年,乏力3月,发现尿蛋白、尿糖阳性2月”入院,低钾血症,低尿酸血症,提示近端肾小管功能损害,血清肌酐临界值104μmol/L,诊断Fanconi综合征。肾活检病理提示,可见灶性小管损伤及炎症细胞浸润,排除过敏、中毒、免疫、肿瘤、遗传等其他因素后,考虑药物相关可能性大,予激素、补钾等治疗后,乏力明显改善,1年后停用激素、补钾药物,肾功能、血钾基本恢复正常。A 25-year-old male patient was admitted to the hospital because of“taking processed traditional Chinese medicine for nearly a year,fatigue for three months with positive urine protein and sugar for two months”.He also had hypokalemia and hypouricemia,uggesting proximal renal tubular impairment,obtained an elevated value of creatinine(SCr 104μmol/L)and diagnosed with Fanconi syndrome.Renal biopsy suggested focal tubular injury and inflammatory cell infiltration.After excluding other factors such as allergy,intoxication,immunity,tumor,and genetics,it was highly considered to be drug related.The patient was treated with prednisone,potassium supplementation and other therapies,with a significant improvement in fatigue.One year later,the patients stopped prednisone and potassium supplementation,and the renal function and blood potassium returned to normal.

关 键 词：FANCONI综合征 低钾血症 药物相关 

分 类 号：R969.3[医药卫生—药理学]