中药活性成分调控凋亡途径干预病理性瘢痕的研究进展  

Research Progress on the Regulation of Apoptosis Pathway by Active Ingredients of Traditional Chinese Medicine in Intervening Pathological Scars

作　　者：李茵 袁茵 李蒙 刘怡然 陈曦[2] LI Yin;YUAN Yin;LI Meng;LIU Yiran;CHEN Xi(School of Pharmacy,Heilongjiang University of Chinese Medicine,Haerbin 150006,China;The Institute of Medicinal Plant Development,Beijing 100193,China;Institute of Medicinal Plant Development Yunnan Branch,Chinese Academy of Medical Science,Jinghong 666100,China;School of Pharmacy,Yunnan University of Chinese Medicine,Kunming 650500,China)

机构地区：[1]黑龙江中医药大学药学院,黑龙江哈尔滨150006 [2]中国医学科学院北京协和医学院药用植物研究所,北京100193 [3]中国医学科学院药用植物研究所云南分所,云南景洪666100 [4]云南中医药大学药学院,云南昆明650500

出　　处：《现代中药研究与实践》2024年第2期97-102,共6页Research and Practice on Chinese Medicines

基　　金：中国医学科学院医学与健康科技创新工程(2021-I2M-1-022)。

摘　　要：中药中萜类、黄酮类、生物碱类、甾体类、酚酸类、胆汁酸类等多种活性成分均可通过凋亡途径,诱导过度增殖的成纤维细胞死亡,减少细胞外基质病理性累积,从而发挥治疗病理性瘢痕的作用。通过对近年凋亡通路在病理性瘢痕中的作用以及中药活性成分干预的研究进展进行综述,以期为治疗病理性瘢痕的新药研发提供思路。Various active ingredients such as terpenes,flavonoids,alkaloids,steroids,phenolic acids and bile acids in traditional Chinese medicine can induce excessive proliferation of fibroblasts through apoptosis,reduce pathological accumulation of extracellular matrix,and thus play a role in treating pathological scars.Therefore,the role of apoptosis pathways in pathological scars in recent years and the research progress on the intervention of traditional Chinese medicine active ingredients are reviewed,in order to provide ideas for the development of new drugs for treating pathological scars.

关 键 词：中药 病理性瘢痕 凋亡途径 作用机制 研究进展 

分 类 号：R285.5[医药卫生—中药学]