职工体检中主要血脂指标对糖尿病患者的早期诊断和预测价值  

Early Diagnosis and Predictive Values of Major Blood Lipid Indicators in Physical Examination of Employees for Diabetes Patients

作　　者：马婧 李廷栋 杨少华 冯渤曦 马鸿婧 刘晓峰 王少华 吴建军 MA Jing;LI Tingdong;YANG Shaohua;FENG Boxi;MA Hongjing;LIU Xiaofeng;WANG Shaohua;WU Jianjun;无(Disease Prevention and Control Institute of China Railway Lanzhou Group Co.,Ltd.,Lanzhou 730000,China;Labor and Health Department of China Railway Lanzhou Group Co.,Ltd.,Lanzhou 730000,China;School of Public Health,Gansu University of Traditional Chinese Medicine,Lanzhou 730000,China)

机构地区：[1]中国铁路兰州局集团有限公司疾病预防控制所,甘肃兰州730000 [2]中国铁路兰州局集团有限公司劳卫部,甘肃兰州730000 [3]甘肃中医药大学公共卫生学院,甘肃兰州730000

出　　处：《西北民族大学学报（自然科学版）》2024年第2期61-67,共7页Journal of Northwest Minzu University(Natural Science)

基　　金：中国铁路兰州局集团有限公司科技研究开发计划课题(LZJKY2021028-3);甘肃省重大疾病分子医学与中医药防治研究重点实验室新型冠状病毒防治研究专项(FZYX20-13);甘肃省高等学校产业支撑计划项目(2020C-36)。

摘　　要：目的:探讨非高密度脂蛋白胆固醇(non-HDL-C)、空腹血清甘油三酯葡萄糖乘积指数(TyG)和血浆致动脉粥样硬化指数(AIP)对糖尿病前期的诊断和预测价值.方法:收集了2020年某铁路企业58030名在职职工的健康数据,采用非条件Logistic回归模型分析non-HDL-C、TyG、AIP与糖尿病前期的关系,并绘制ROC曲线评估这些指标的预测能力.结果:2020年该企业58030名职工糖尿病前期患病率为6.3%.相关性分析发现随着non-HDL-C(r=0.095,P<0.05)、TyG(r=0.211,P<0.05)和AIP(r=0.113,P<0.05)的增加,糖尿病前期患病率逐渐升高.二元Logistic回归分析显示,non-HDL-C(OR=1.472,95%CI=1.423~1.523)、TyG(OR=3.929,95%CI=3.723~4.145)和AIP(OR=4.324,95%CI=3.897~4.797)均为糖尿病前期患病的影响因素.ROC曲线分析进一步证明了non-HDL-C、TyG和AIP对糖尿病前期的预测作用.结论:non-HDL-C、TyG和AIP在筛查中有助于早期预警诊断潜在的糖尿病患者.Objective The present article aimed to investigate the diagnostic and predictive value of non-high-density lipoprotein cholesterol(non-HDL-C),fasting serum triglycerides-glucose(TyG)index,and atherogenic index of plasma(AIP)for prediabetes,and to provide theoretical basis for early prevention and control of diabetes.Methods Health data were collected from 58030 employees of a railway enterprise in 2020.The unconditional logistic regression models was utilized to analyze the relationship between non-HDL-C,TyG index,AIP index and prediabetes.ROC curves were plotted to assess the predictive ability of these indicators.Results In 2020,the prevalence of prediabetes among 58,031 employees of the enterprise was 6.3%.Correlation analysis found that as non-HDL-C(r=0.095,P<0.05),TyG(r=0.211,P<0.05),AIP(r=0.113,P<0.05)were increased,the prevalence of prediabetes gradually increased.Binary logistic regression analysis showed that non-HDL-C(OR=1.472,95%CI=1.423-1.523),TyG(OR=3.929,95%CI=3.723-4.145),and AIP(OR=4.324,95%CI=3.897-4.797)were all influencing factors for prediabetes.ROC curve analysis further confirmed the predictive role of non-HDL-C,TyG index,and AIP index for prediabetes.Conclusion Non-HDL-C,TyG index and AIP index contributed to the early warning and diagnosis of potential diabetes patients in screening.

关 键 词：铁路职工 非高密度脂蛋白胆固醇 血清甘油三酯葡萄糖乘积指数 血浆致动脉硬化指数 

分 类 号：R587.1[医药卫生—内分泌]