血清Ang-2和HMGB1水平与脓毒症患者病情及预后相关性的研究  

Study on the correlation between serum Ang-2 and HMGB1 and prognosis in patients with sepsis

作　　者：卢燕[1] 王敏[2] 李学莉[1] LU Yan;WANG Min;LI Xueli(The First People′s Hospital of Yinchuan,Yinchuan 750001,China;The First Hospital of Wuhan,Wuhan 430022,China)

机构地区：[1]宁夏银川市第一人民医院,宁夏银川750001 [2]湖北省武汉市第一医院,湖北武汉430022

出　　处：《宁夏医学杂志》2024年第6期465-469,F0003,共6页Ningxia Medical Journal

基　　金：宁夏医科大学校级科研重点项目(XZ2023032)。

摘　　要：目的 探究血清血管生成素-2(Ang-2)和高迁移率族蛋白B1(HMGB1)水平与脓毒症患者病情及28天预后的相关性。方法 回顾性分析41例脓毒症患者资料,根据患者28天的预后情况分为存活组和死亡组;根据患者病情严重程度将2组患者分别分为脓毒症组和脓毒性休克组。记录所有入组患者的一般资料并进行第1天、第3天、第5天及第7天的APACHEⅡ评分,测定Ang-2和HMGB1水平。结果 存活组与死亡组患者的一般资料比较差异无统计学意义。死亡组脓毒症休克患者占比及入科APACHEⅡ评分为(85.71%)和(29.29±5.99)分,均明显高于存活组(51.84%)和(24.96±5.84)分。2组患者血清Ang-2和HMGB1水平比较差异无统计学意义。第7天的HMGB1水平与脓毒症患者预后显著相关,而第1天、第3天、第5天的HMGB1水平及上述各时间点的Ang-2水平与患者预后均无相关性。各时间点血清Ang-2水平的算术平均值与APACHEⅡ评分的算术平均值呈正相关,HMGB1水平与APACHEⅡ评分并无相关性。联合第7天的APACHEⅡ评分、Ang-2和HMGB1水平的曲线下面积最大为0.78,灵敏度为92.9%,特异度为59.3%。联合第7天的Ang-2和HMGB1水平预测预后不良的曲线下面积为0.71,灵敏度为92.9%,特异度为55.6%。结论 脓毒症患者第1天、第3天、第5天及第7天的平均血清Ang-2水平与病情严重程度呈正相关;联合脓毒症患者第7天的血清Ang-2和HMGB1水平对其预后进行评估灵敏度最高,明显高于单独某项指标的评估价值。Objective[HJ2mm]To study the correlation between the serum levels of angiopoietin-2(Ang-2)and high mobility group protein B1(HMGB1)with the condition and 28 day prognosis of sepsis patients.Methods A retrospective analysis was performed on the data of 41 patients with sepsis.According to the prognosis of the patients in 28 days,they were divided into survival group and death group,and according to the severity of the patients,they were divided into sepsis group and septic shock group.The general information of patients were recorded,and APACHEⅡscores on the 1st,3rd,5th,and 7th day of diagnosis were performed.The levels of Ang-2 and HMGB1 were measured.Results There was no significant difference in the general information between the survival group and the death group.The proportion of patients with septic shock(85.71%)and APACHEⅡscore(29.29±5.99)in the death group were significantly higher than those in the survival group(51.84%,24.96±5.84).There was no significant difference in serum Ang-2 and HMGB1 between the two groups.The level of HMGB1 on the 7th day was significantly correlated with the prognosis of patients with sepsis,while the levels of HMGB1 and Ang-2 on the 1st,3rd,and 5th days were not correlated with the prognosis.The arithmetic mean of serum Ang-2 levels at the four time points was positively correlated with the arithmetic mean of the APACHEⅡscore,but the HMGB1 levels had no correlation with the APACHEⅡscore.The maximum area under the curve for the APACHEⅡscore,Ang-2 and HMGB1 levels on the 7th day of combination was 0.78,with a sensitivity of 92.9%and specificity of 59.3%.The area under the curve for predicting prognosis by combining Ang-2 and HMGB1 levels on the 7th day was 0.71 the sensitivity and specificity were 92.9%and 55.6%.Conclusion The average serum levels of Ang-2 on the 1 st,3 rd,5 th,and 7 th day are positively correlated with the severity of the disease.The serum levels of Ang-2 and HMGB1 on the 7 th day have the highest sensitivity for assessing the prognosis of patients

关 键 词：脓毒症 血管生成素-2 高迁移率族蛋白B1 预后 

分 类 号：G353.1[文化科学—情报学]