血清DUSP1表达对急性肺血栓栓塞患者的预后价值研究  

Prognostic value of serum DUSP1 expression in patients with acute pulmonary thromboembolism

作　　者：柏松 黄博雅 李津 张竹芬 张毅茹 曹玉萍[1] 张国彦[1] BAI Song;HUANG Boya;LI Jin;ZHANG Zhufen;ZHANG Yiru;CAO Yuping;ZHANG Guoyan(First Department of Emergency,Baoding First Central Hospital,Baoding,Hebei 071000,China)

机构地区：[1]保定市第一中心医院急诊一科,河北保定071000

出　　处：《国际检验医学杂志》2024年第13期1606-1610,共5页International Journal of Laboratory Medicine

基　　金：保定市科学技术研究与发展计划项目(2141ZF085)。

摘　　要：目的 探究血清双特异性磷酸酶1(DUSP1)表达水平对急性肺血栓栓塞(APTE)患者的预后价值。方法 选取该院2020年3月至2022年7月收治的112例APTE患者作为观察组,并选取同期在该院行体检的健康者50例作为对照组。治疗后随访6个月,根据预后状况将APTE患者分为预后良好组(90例)和预后不良组(22例)。比较入院前各组间的血清DUSP1相对表达水平及肺栓塞严重程度指数(PESI)评分;采用Spearman相关性分析血清DUSP1相对表达水平与PESI评分之间的关系;采用受试者工作特征(ROC)曲线分析血清DUSP1相对表达水平及PESI评分对APTE患者预后的预测价值。结果 与对照组比较,观察组血清DUSP1相对表达水平升高(P<0.05);不同危险度患者血清DUSP1相对表达水平及PESI评分比较差异有统计学意义(P<0.05),高危APTE患者血清DUSP1相对表达水平及PESI评分均高于中危患者(P<0.05),中危患者均高于低危患者(P<0.05);Spearman相关性分析显示,血清DUSP1相对表达水平与PESI评分呈正相关(r=0.561,P<0.05);ROC曲线结果显示,DUSP1、PESI评分单独预测APTE患者预后不良的曲线下面积(AUC)分别为0.789、0.867,灵敏度分别为65.8%、86.8%,特异度分别为44.2%、67.2%,二者联合预测APTE患者预后不良的AUC为0.952,其灵敏度、特异度分别为92.1%、75.6%。结论 APTE患者血清DUSP1相对表达水平升高,且随着病情的加重,血清DUSP1相对表达水平逐渐增加,DUSP1是预测APTE患者预后不良的有效指标。Objective To investigate the prognostic value of serum bispecific phosphatase 1(DUSP1)expression level in patients with acute pulmonary thromboembolism(APTE).Methods A total of 112 patients with APTE admitted to the hospital from March 2020 to July 2022 were enrolled as the observation group,and 50 healthy individuals who underwent physical examinations in the hospital during the same period were enrolled as the control group.The APTE patients were followed up for 6 months after treatment,and were grouped into a good prognosis group(90 cases)and a poor prognosis group(22 cases)based on their prognosis.The serum DUSP1 relative expression level and pulmonary embolism severity index(PESI)score were compared among the groups before admission.Spearman correlation was applied to analyze the relationship between serum DUSP1 relative expression level and PESI score.Receiver operating characteristic(ROC)curve was applied to analyze the predictive value of serum DUSP1 relative expression level and PESI score on the prognosis of APTE patients.Results Compared with the control group,the serum DUSP1 relative expression level in the observation group was increased(P<0.05).There were statistically significant differences in serum DUSP1 relative expression level and PESI score among patients with different risk levels(P<0.05),the serum DUSP1 relative expression level and PESI score in high-risk APTE patients were higher than those in medium-risk patients(P<0.05),and those in medium-risk patients were higher than those in low-risk patients(P<0.05).Spearman correlation analysis showed that serum DUSP1 relative expression level was positively correlated with PESI score(r=0.561,P<0.05).ROC curve results showed that the area under the curve(AUC)of DUSP1 and PESI score alone for predicting the poor prognosis in APTE patients was 0.789 and 0.867,with sensitivity of 65.8%and 86.8%,specificity of 44.2%and 67.2%,respectively.The AUC of the combination of the two for predicting the poor prognosis in APTE patients was 0.952,with sensitivity

关 键 词：急性肺血栓栓塞 双特异性磷酸酶1 栓塞严重程度指数 预后 

分 类 号：R446.6[医药卫生—诊断学]