成人隐匿性自身免疫性糖尿病的生物学标志物研究进展  

Research progress on biomarkers of adult-onset latent autoimmune diabetes

作　　者：郭姣姣 刘师伟[1] GUO Jiaojiao;LIU Shiwei(The Third Hospital of Shanxi Medical University(Shanxi Bethune Hospital,Shanxi Academy of Medical Science,Tongji Shanxi Hospital),Taiyuan 030032,China)

机构地区：[1]山西医科大学第三医院(山西白求恩医院山西医学科学院同济山西医院),山西太原030032

出　　处：《新医学》2024年第6期474-479,共6页Journal of New Medicine

基　　金：山西省基础研究计划项目(20210302123487);内分泌代谢病山西省重点实验室(202104010910009)。

摘　　要：成人隐匿性自身免疫性糖尿病(LADA)是一种成年起病的自身免疫性糖尿病,大部分LADA患者在发病初期易被误诊为1型或2型糖尿病。对LADA患者进行非标准化的管理不利于保护其残余胰岛β细胞功能,而且会增加早期并发症的发生风险和病死率。文章从基因、转录、蛋白质、代谢组学、炎症等方面综述可能预测LADA的生物学标志物,旨在为早期识别并诊断LADA,以及延缓LADA患者胰岛β细胞功能衰竭提供参考。Adult-onset latent autoimmune diabetes(LADA)represents an autoimmune form of diabetes that emerges in the adult population.Frequently,individuals with LADA are initially misdiagnosed as type 1 or type 2 diabetes mellitus.Nonstandard management of LADA patients can impede efforts to preserve the remaining functionality of pancreatic islet beta-cells,elevate the risk of early complications of diabetes and increase the mortality rate.This review offers a comprehensive examination of various biomarkers,encompassing genetic factors,transcriptional profiles,proteins,metabolomic markers,and inflammatory indices,which may be employed to forecast the onset of LADA,aiming to facilitate prompt recognition and diagnosis of LADA,thereby retarding the progressive deterioration of pancreatic islet beta-cell function.

关 键 词：成人 隐匿性自身免疫性糖尿病 1型糖尿病 2型糖尿病 生物学标志物 

分 类 号：R587.1[医药卫生—内分泌]