社区早筛抗线粒体抗体阳性的中医药早期干预效果分析  

Analysis on the Effect of Traditional Chinese Medicine in the Early Intervention of Positive Anti-mitochondrial Antibody in Community Early Screening

作　　者：刘贝 罗志宇 蒋式骊[4] LIU Bei;LUO Zhiyu;JIANG Shili(Department of Traditional Chinese Medicine,Longhua Street Community Health Service Center of Xuhui District,Shanghai 200232,China;Shanghai Greenvalley Pharmaceutical Co.,Ltd.,Shanghai 201203,China;Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201210,China;Hepatology Department,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)

机构地区：[1]上海市徐汇区龙华街道社区卫生服务中心中医科,上海200232 [2]上海绿谷制药有限公司,上海201203 [3]中国科学院上海药物研究所,上海201210 [4]上海中医药大学附属曙光医院肝病科,上海201203

出　　处：《中国中医药现代远程教育》2024年第16期101-104,共4页Chinese Medicine Modern Distance Education of China

基　　金：上海市卫生和计划生育委员会科研课题项目【No.201640332】;上海市科委“科技创新行动计划”临床医学领域科技支撑项目【No.19401972600】。

摘　　要：目的探讨社区早筛抗线粒体抗体阳性的中医药早期干预效果。方法选取前期从龙华、凌云、康健3个社区20000个案例中筛查出的106例单纯抗线粒体抗体阳性患者作为研究对象,随机分为研究组和对照组,每组53例,分析两组肝功能指标及中医体质辨识评分变化情况。结果治疗前,两组肝功能检测结果差异无统计学意义(P>0.05);治疗后,与对照组相比,研究组总胆红素(TBil)水平显著降低,差异有统计学意义(P<0.01)。运用“中医体质分类与判定”量表对两组患者进行中医体质辨识分型,治疗前两组体质分类和总体评分差异无统计学意义(P>0.05);治疗后,两组体质变化差异无统计学意义,但研究组总体评分降低,其中最常发生的5种症状——干燥、便秘、喜饮水、口苦、小便黄,研究组相关评分较对照组明显降低,差异有统计学意义(P<0.05)。结论对社区早筛抗线粒体抗体阳性患者进行中医药早期干预有利于改善不适症状,提高生活质量,值得进一步研究。Objective To investigate the early intervention effect of traditional Chinese medicine in community early screening pa⁃tients positive with anti-mitochondrial antibodies.Methods A total of 106 positive patients with simple anti-mitochondrial antibody were selected from 20,000 community cases in Longhua,Lingyun and Kangjian communities for early intervention of traditional Chi⁃nese medicine.They were randomly divided into study group and control group,with 53 cases in each group.The changes of liver func⁃tion and TCM physique identification scores of the two groups were analyzed.Results Before treatment,there was no significant differ⁃ence in the liver function test results between the two groups(P>0.05).After treatment,compared with the control group,the level of to⁃tal bilirubin in the study group was significantly decreased(P<0.01).According to the scale of TCM Constitution Classification and Judgment,there were no significant differences in constitution classification and overall score between the two groups before treatment(P>0.05).After treatment,there was no significant difference in physical changes,but the overall score of the study group was de⁃creased,among which the five most common symptoms of dryness,constipation,drinking,bitter mouth and yellow urine score were sig⁃nificantly decreased in the study group,and the difference between the two groups was significant(P<0.05).Conclusion Early inter⁃vention of traditional Chinese medicine in community early screening patients positive with anti-mitochondrial antibodies is beneficial to improve the symptoms of discomfort and improve the quality of life,which is worthy of further research.

关 键 词：抗线粒体抗体阳性 社区早筛 中医体质辨识 

分 类 号：R259[医药卫生—中西医结合]