气体微泡光声造影剂的靶向修饰与应用  

Targeted modification and application of gas microbubble photoacoustic contrast agents

作　　者：陈君[1] 陈常云[2] 蔡成美 冯梅 孙霞[2] 魏咏梅[2] CHEN Jun;CHEN Changyun;CAI Chengmei;FENG Mei;SUN Xia;WEI Yongmei(Department of Ultrasound,Shouguang People's Hospital,Weifang,Shandong 262700,China;Health Management Center,Rizhao Traditional Chinese Medicine Hospital,Rizhao,Shandong 276800,China;Ji'nan Vocational Nursing College,Ji'nan,Shandong 250100,China)

机构地区：[1]寿光市人民医院超声科,山东潍坊262700 [2]日照市中医医院健康管理中心,山东日照276800 [3]济南职业护理学院,山东济南250100

出　　处：《影像研究与医学应用》2024年第13期13-15,共3页Journal of Imaging Research and Medical Applications

摘　　要：气体微泡作为一种新型的光声造影剂,由于其具有生物相容性良好、成像灵敏度高、易于修饰等优点,在生物医学成像领域引起了广泛的关注。然而,气体微泡的非靶向性限制了其在临床上的应用。为了提高气体微泡的光声造影剂的靶向性和特异性,需要对其进行靶向修饰。本文综述气体微泡的光声造影剂的靶向修饰方法,包括物理修饰法、化学修饰法和生物修饰法,阐述气体微泡的光声造影剂的靶向修饰在肿瘤成像、炎症成像、感染成像和血管成像中的应用,分析气体微泡的光声造影剂的靶向修饰的优势和局限性,展望未来的发展方向。Gas microbubbles,as a new type of photoacoustic contrast agent,have attracted widespread attention in the field of biomedical imaging due to their good biocompatibility,high imaging sensitivity,and ease of modification.However,the non targeting nature of gas microbubbles limits their clinical application.In order to improve the targeting and specificity of gas microbubbles as photoacoustic contrast agents,targeted modification is needed.This article reviews the targeted modification methods of gas microbubbles for photoacoustic contrast agents,including physical modification,chemical modification,and biological modification.The application of targeted modification of gas microbubbles as photoacoustic contrast agents in tumor imaging,inflammation imaging,infection imaging,and vascular imaging was elucidated.Analyze the advantages and limitations of targeted modification of gas microbubbles using photoacoustic contrast agents,and look forward to future development directions.

关 键 词：气体微泡 光声造影剂 靶向修饰 生物医学成像 

分 类 号：R445[医药卫生—影像医学与核医学]