2型糖尿病合并骨质疏松患者PTH及ER基因多态性分析  

Analysis of PTH and ER Gene Polymorphisms in Patients with Type 2 Diabetes Mellitus Complicated with Osteoporosis

作　　者：牛玲[1] 马蓉 张程 苗翠娟 唐艳[1] 刘方 李博一[1] NIU Ling;MA Rong;ZHANG Cheng;MIAO Cuijuan;TANG Yan;LIU Fang;LI Boyi(Dept.of Endocrinology and Clinical Laboratory,The 1st People’s Hospital of Kunmig,Kunming Yunnan 650011,China)

机构地区：[1]昆明市第一人民医院内分泌科,云南昆明650011

出　　处：《昆明医科大学学报》2024年第6期106-112,共7页Journal of Kunming Medical University

基　　金：昆明市卫生科技人才培养项目医学科技学科后备人才基金资助项目[2022-SW(后备)-35];昆明市卫生健康委员会卫生科研课题基金资助项目(2022-03-06-007)。

摘　　要：目的探讨2型糖尿病(type 2 diabetes mellitus,T2DM)合并骨质疏松(osteoporosis,OP)患者甲状旁腺素(parathyroid hormone,PTH)及雌激素受体(estrogen receptor,ER)基因多态性特点。方法选取2022年11月至2023年10月在昆明市第一人民医院内分泌科住院的来自昆明地区T2DM患者110例,根据骨密度结果将其分组为T2DM无OP组(n=68,T≥-1.0)、T2DM伴OP组(n=42,T≤-2.5),检测其PTH及ER基因型及等位基因频率,比较其与性别、身高、体重等临床指标间的差异。结果回归分析显示,T2DM合并OP与患者性别、体重相关(P<0.05),而PTH基因、ER基因多态性则无相关性(P>0.05)。结论性别和体重是T2DM患者骨质疏松发生的独立危险因素;PTH基因、ER基因多态性与昆明地区T2DM伴OP的遗传易感性无关。Objective To investigate the characteristics of parathyroid hormone(PTH)and estrogen receptor(ER)gene polymorphisms in patients with type 2 diabetes mellitus(T2DM)complicated with osteoporosis(OP).Methods 110 patients with T2DM from Kunming area were selected in the 1st People's Hospital of Kunming Endocrinology Department from November 2022 to October 2023,and were divided into T2DM without OP group(n=68,T≥-1.0),T2DM with OP group(n=42,T≤-2.5),according to the results of bone mineral density,the genotype and allele frequency of PTH and ER were detected,and the differences between them and gender,height,weight and other clinical indicators were compared.Results Regression analysis showed that T2DM with OP was related to gende and weight(P<0.05),but not related to PTH gene,or ER gene polymorphism(P>0.05).Conclusion Gender and weight are independent risk factors for osteoporosis in patients with type 2 diabetes mellitus;gene polymorphism of PTH and ER are not related to the genetic susceptibility of T2DM with OP in Kunming area.

关 键 词：基因多态性 2型糖尿病 骨质疏松症 

分 类 号：R587.1[医药卫生—内分泌]