异位嗅觉受体的功能及其作为药物靶点的研究进展  

Research progress on the function of ectopic olfactory receptors and their value as drug targets

作　　者：刘畅[1] 赵永馨 葛蓓蓓 卫彬[1] 高勇[1] LIU Chang;ZHAO Yongxin;GE Beibei;WEI Bin;GAO Yong(Department of Medical Oncology,The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University,Huaian 223000,China)

机构地区：[1]南京医科大学附属淮安第一医院肿瘤内科,淮安223000

出　　处：《中国药科大学学报》2024年第3期412-419,共8页Journal of China Pharmaceutical University

基　　金：国家自然科学基金项目(No.82103318);江苏省自然科学基金项目(No.BK20211112)。

摘　　要：嗅觉受体(olfactory receptors,ORs)是一类主要在鼻上皮嗅觉感觉神经元中分布的跨膜蛋白,介导气味向大脑传递实时感觉信号而产生嗅觉。近年来研究发现,ORs也可在鼻腔外组织或器官中表达,且与多种生物过程密切相关,如精子趋化性、伤口愈合、糖脂代谢及肠道分泌等。此外,ORs还与前列腺癌、乳腺癌及结直肠癌等多种恶性肿瘤关系密切,通过调节细胞增殖、凋亡、迁移及侵袭等过程影响肿瘤的发生发展。本文概述了异位ORs对人体组织器官功能的影响,并评估它们作为治疗疾病的药物靶点的潜在价值。Olfactory receptors(ORs)are transmembrane proteins mainly distributed in olfactory sensory neurons of the nasal epithelium,mediating the transmission of real-time sensory signals to the brain to produce smell.Recent studies have reported that ORs can also be expressed in tissues or organs outside the nasal cavity,and are closely related to a variety of biological processes,such as sperm chemotaxis,wound healing,glycolipid metabolism and intestinal secretion.In addition,ORs are closely related to a variety of malignant tumors such as prostate cancer,breast cancer and colorectal cancer,and may affect the occurrence and development of tumors by regulating cell proliferation,apoptosis,migration and invasion.This review provides an overview of the effects of ectopic ORs on the function of various human tissues and organs and assesses their potential value as drug targets for the treatment of human diseases.

关 键 词：嗅觉受体 G蛋白偶联受体 异位表达 生物学功能 恶性肿瘤 药物靶点 

分 类 号：R966[医药卫生—药理学]